TY - JOUR
T1 - Clinical features and prognostic factors in patients with head and neck cancer: Results from a multicentric study.
AU - Leoncini, Emanuele
AU - Vukovic, Vladimir
AU - Cadoni, Gabriella
AU - Pastorino, Roberta
AU - Arzani, Dario
AU - Bosetti, Cristina
AU - Canova, Cristina
AU - Garavello, Werner
AU - La Vecchia, Carlo
AU - Maule, Milena
AU - Petrelli, Livia
AU - Pira, Enrico
AU - Polesel, Jerry
AU - Richiardi, Lorenzo
AU - Serraino, Diego
AU - Simonato, Lorenzo
AU - Ricciardi, Walter
AU - Boccia, Stefania
PY - 2015
Y1 - 2015
N2 - Abstract
BACKGROUND:
The purpose of this study is to evaluate whether demographics, lifestyle habits, clinical data and alcohol dehydrogenase polymorphisms rs1229984 and rs1573496 associated with first primary head and neck (HNC) are associated with overall survival, recurrence, and second primary cancer (SPC).
METHODS:
We conducted a follow-up study in five centres including 801 cases. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for overall survival, recurrence and SPC.
RESULTS:
Five-years overall survival was 62% for HNC cases, 55% for oral cavity, 53% for oropharynx, 41% for hypopharynx, and 71% for larynx. Predictors of survival were older ages (HR=1.18 for 5 years increase; CI: 1.07-1.30), higher tumour stage (HR=4.16; CI: 2.49-6.96), and high alcohol consumption (HR=3.93; CI: 1.79-8.63). A combined therapy (HR=3.29; CI: 1.18-9.13) was associated with a worst prognosis for oral cavity cancer. The only predictor was higher tumour stage (HR=2.25; CI: 1.26-4.03) for recurrence, and duration of smoking (HR=1.91; CI: 1.00-3.68) for SPC. ADH1B rs1229984 polymorphism HRs for HNC and oesophageal cancer death and for alcohol related cancer death were 0.67 (95% CI: 0.42-1.08), and 0.64 (95% CI: 0.40-1.03), respectively.
CONCLUSIONS:
The survival expectation differs among HNC sites. Increasing age and stage, and high alcohol consumption were unfavourable predictors of HNC survival overall. Duration of tobacco consumption before the first primary tumour was a risk factor for SPC.
AB - Abstract
BACKGROUND:
The purpose of this study is to evaluate whether demographics, lifestyle habits, clinical data and alcohol dehydrogenase polymorphisms rs1229984 and rs1573496 associated with first primary head and neck (HNC) are associated with overall survival, recurrence, and second primary cancer (SPC).
METHODS:
We conducted a follow-up study in five centres including 801 cases. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for overall survival, recurrence and SPC.
RESULTS:
Five-years overall survival was 62% for HNC cases, 55% for oral cavity, 53% for oropharynx, 41% for hypopharynx, and 71% for larynx. Predictors of survival were older ages (HR=1.18 for 5 years increase; CI: 1.07-1.30), higher tumour stage (HR=4.16; CI: 2.49-6.96), and high alcohol consumption (HR=3.93; CI: 1.79-8.63). A combined therapy (HR=3.29; CI: 1.18-9.13) was associated with a worst prognosis for oral cavity cancer. The only predictor was higher tumour stage (HR=2.25; CI: 1.26-4.03) for recurrence, and duration of smoking (HR=1.91; CI: 1.00-3.68) for SPC. ADH1B rs1229984 polymorphism HRs for HNC and oesophageal cancer death and for alcohol related cancer death were 0.67 (95% CI: 0.42-1.08), and 0.64 (95% CI: 0.40-1.03), respectively.
CONCLUSIONS:
The survival expectation differs among HNC sites. Increasing age and stage, and high alcohol consumption were unfavourable predictors of HNC survival overall. Duration of tobacco consumption before the first primary tumour was a risk factor for SPC.
KW - head and neck cancer
KW - prognostic factors
KW - head and neck cancer
KW - prognostic factors
UR - http://hdl.handle.net/10807/66112
U2 - 10.1016/j.canep.2015.02.004
DO - 10.1016/j.canep.2015.02.004
M3 - Article
SN - 1877-7821
VL - 39
SP - 367
EP - 374
JO - Cancer Epidemiology
JF - Cancer Epidemiology
ER -
