TY - JOUR
T1 - Clinical characteristics and predictors of mortality associated with COVID-19 in elderly patients from a long-term care facility
AU - Trecarichi, Enrico Maria
AU - Mazzitelli, Maria
AU - Serapide, Francesca
AU - Pelle, Maria Chiara
AU - Tassone, Bruno
AU - Arrighi, Eugenio
AU - Perri, Graziella
AU - Fusco, Paolo
AU - Scaglione, Vincenzo
AU - Davoli, Chiara
AU - Lionello, Rosaria
AU - La Gamba, Valentina
AU - Marrazzo, Giuseppina
AU - Busceti, Maria Teresa
AU - Giudice, Amerigo
AU - Ricchio, Marco
AU - Cancelliere, Anna
AU - Lio, Elena
AU - Procopio, Giada
AU - Costanzo, Francesco Saverio
AU - Foti, Daniela Patrizia
AU - Matera, Giovanni
AU - Torti, Carlo
PY - 2020
Y1 - 2020
N2 - Since December 2019, coronavirus disease 2019 (COVID-19) pandemic has spread from China all over the world and many COVID-19 outbreaks have been reported in long-term care facilities (LCTF). However, data on clinical characteristics and prognostic factors in such settings are scarce. We conducted a retrospective, observational cohort study to assess clinical characteristics and baseline predictors of mortality of COVID-19 patients hospitalized after an outbreak of SARS-CoV-2 infection in a LTCF. A total of 50 patients were included. Mean age was 80 years (SD, 12 years), and 24/50 (57.1%) patients were males. The overall in-hospital mortality rate was 32%. At Cox regression analysis, significant predictors of in-hospital mortality were: hypernatremia (HR 9.12), lymphocyte count < 1000 cells/µL (HR 7.45), cardiovascular diseases other than hypertension (HR 6.41), and higher levels of serum interleukin-6 (IL-6, pg/mL) (HR 1.005). Our study shows a high in-hospital mortality rate in a cohort of elderly patients with COVID-19 and hypernatremia, lymphopenia, CVD other than hypertension, and higher IL-6 serum levels were identified as independent predictors of in-hospital mortality. Given the small population size as major limitation of our study, further investigations are necessary to better understand and confirm our findings in elderly patients.
AB - Since December 2019, coronavirus disease 2019 (COVID-19) pandemic has spread from China all over the world and many COVID-19 outbreaks have been reported in long-term care facilities (LCTF). However, data on clinical characteristics and prognostic factors in such settings are scarce. We conducted a retrospective, observational cohort study to assess clinical characteristics and baseline predictors of mortality of COVID-19 patients hospitalized after an outbreak of SARS-CoV-2 infection in a LTCF. A total of 50 patients were included. Mean age was 80 years (SD, 12 years), and 24/50 (57.1%) patients were males. The overall in-hospital mortality rate was 32%. At Cox regression analysis, significant predictors of in-hospital mortality were: hypernatremia (HR 9.12), lymphocyte count < 1000 cells/µL (HR 7.45), cardiovascular diseases other than hypertension (HR 6.41), and higher levels of serum interleukin-6 (IL-6, pg/mL) (HR 1.005). Our study shows a high in-hospital mortality rate in a cohort of elderly patients with COVID-19 and hypernatremia, lymphopenia, CVD other than hypertension, and higher IL-6 serum levels were identified as independent predictors of in-hospital mortality. Given the small population size as major limitation of our study, further investigations are necessary to better understand and confirm our findings in elderly patients.
KW - COVID-19 / mortality
KW - COVID-19 / mortality
UR - http://hdl.handle.net/10807/303904
U2 - 10.1038/s41598-020-77641-7
DO - 10.1038/s41598-020-77641-7
M3 - Article
SN - 2045-2322
VL - 10
SP - N/A-N/A
JO - Scientific Reports
JF - Scientific Reports
ER -