Clinical and ultrasonographic predictors of joint replacement for knee osteoarthritis: Results from a large, 3-year, prospective EULAR study

Maria Antonietta D'Agostino, P. G. Conaghan, M. A. D'Agostino, M. Le Bars, G. Baron, N. Schmidely, R. Wakefield, P. Ravaud, W. Grassi, E. Martin-Mola, A. So, M. Backhaus, M. Malaise, P. Emery, M. Dougados

Risultato della ricerca: Contributo in rivistaArticolo in rivista

119 Citazioni (Scopus)

Abstract

Objectives: To determine clinical and ultrasonographic predictors of joint replacement surgery across Europe in primary osteoarthritis (OA) of the knee. Methods: This was a 3-year prospective study of a painful OA knee cohort (from a EULAR-sponsored, multicentre study). All subjects had clinical evaluation, radiographs and ultrasonography (US) at study entry. The rate of knee replacement surgery over the 3-year follow-up period was determined using Kaplan-Meier survival data analyses. Predictive factors for joint replacement were identified by univariate log-rank test then multivariate analysis using a Cox proportional-hazards regression model. Potential baseline predictors included demographic, clinical, radiographic and US features. Results: Of the 600 original patients, 531 (88.5%), mean age 67±10 years, mean disease duration 6.1±6.9 years, had follow-up data and were analysed. During follow-up (median 3 years; range 0-4 years), knee replacement was done or required for 94 patients (estimated event rate of 17.7%). In the multivariate analysis, predictors of joint replacement were as follows: Kellgren and Lawrence radiographic grade (grade ≥III vs
Lingua originaleEnglish
pagine (da-a)644-647
Numero di pagine4
RivistaANNALS OF THE RHEUMATIC DISEASES
Volume69
DOI
Stato di pubblicazionePubblicato - 2010

Keywords

  • Aged
  • Arthroplasty, Replacement, Knee
  • Epidemiologic Methods
  • Exudates and Transudates
  • Female
  • Humans
  • Knee Joint
  • Male
  • Middle Aged
  • Osteoarthritis, Knee
  • Pain Measurement
  • Prognosis
  • Radiography
  • Ultrasonography
  • Disease Progression

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