Abstract
Objectives: To determine clinical and ultrasonographic predictors of joint replacement surgery across Europe in primary osteoarthritis (OA) of the knee. Methods: This was a 3-year prospective study of a painful OA knee cohort (from a EULAR-sponsored, multicentre study). All subjects had clinical evaluation, radiographs and ultrasonography (US) at study entry. The rate of knee replacement surgery over the 3-year follow-up period was determined using Kaplan-Meier survival data analyses. Predictive factors for joint replacement were identified by univariate log-rank test then multivariate analysis using a Cox proportional-hazards regression model. Potential baseline predictors included demographic, clinical, radiographic and US features. Results: Of the 600 original patients, 531 (88.5%), mean age 67±10 years, mean disease duration 6.1±6.9 years, had follow-up data and were analysed. During follow-up (median 3 years; range 0-4 years), knee replacement was done or required for 94 patients (estimated event rate of 17.7%). In the multivariate analysis, predictors of joint replacement were as follows: Kellgren and Lawrence radiographic grade (grade ≥III vs
Lingua originale | Inglese |
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pagine (da-a) | 644-647 |
Numero di pagine | 4 |
Rivista | Annals of the Rheumatic Diseases |
Volume | 69 |
Numero di pubblicazione | 4 |
DOI | |
Stato di pubblicazione | Pubblicato - 2010 |
All Science Journal Classification (ASJC) codes
- Immunologia e Allergia
- Reumatologia
- Immunologia
- Biochimica, Genetica, Biologia Molecolare Generali
Keywords
- Aged
- Arthroplasty
- Disease Progression
- Epidemiologic Methods
- Exudates and Transudates
- Female
- Humans
- Knee
- Knee Joint
- Male
- Middle Aged
- Osteoarthritis
- Pain Measurement
- Prognosis
- Radiography
- Replacement
- Ultrasonography