Classical pediatric Hodgkin lymphoma in very young patients: the Italian experience

Piero Farruggia; Giuseppe Puccio; Franco Locatelli; Mariarita Vetro; Marta Pillon; Angela Trizzino; Alessandra Sala; Salvatore Buffardi; Alberto Garaventa; Francesca Rossi; Maurizio Bianchi; Marco Zecca; Andrea Pession; Claudio Favre; Salvatore D’Amico; Massimo Provenzi; Giulio Andrea Zanazzo; Antonella Sau; Nicola Santoro; Rosamaria Mura; Caterina Elia; Tommaso Casini; Maurizio Mascarin; Roberta Burnelli

doi:10.1080/10428194.2018.1493732

Classical pediatric Hodgkin lymphoma in very young patients: the Italian experience

Piero Farruggia, Giuseppe Puccio, Franco Locatelli, Mariarita Vetro, Marta Pillon, Angela Trizzino, Alessandra Sala, Salvatore Buffardi, Alberto Garaventa, Francesca Rossi, Maurizio Bianchi, Marco Zecca, Andrea Pession, Claudio Favre, Salvatore D’Amico, Massimo Provenzi, Giulio Andrea Zanazzo, Antonella Sau, Nicola Santoro, Rosamaria MuraCaterina Elia, Tommaso Casini, Maurizio Mascarin, Roberta Burnelli

Risultato della ricerca: Contributo in rivista › Articolo in rivista

Abstract

Many studies have reported a more favorable outcome in younger patients with Hodgkin lymphoma (HL). The aims of this study were to find an appropriate age cutoff able to identify low-risk children and to describe the natural history of 135 very young patients affected by classic HL (cHL). The best age cutoff was identified at 7 years of age. EFS (p =.0451) and PFS (p =.00921) were significantly better in the group of younger patients. The OS rate at 10 years was 97.0% in the younger group and 92.5% in the older one (p =.0448). However, age was not found to be an independent prognostic factor in multivariate analysis and the better prognosis in younger patients seems to be related to more favorable disease characteristics at presentation.

Lingua originale	English
pagine (da-a)	696-702
Numero di pagine	7
Rivista	LEUKEMIA & LYMPHOMA
Volume	60
DOI	https://doi.org/10.1080/10428194.2018.1493732
Stato di pubblicazione	Pubblicato - 2019

Keywords

chemotherapeutic approaches
pediatric
Lymphoma and Hodgkin disease

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10.1080/10428194.2018.1493732

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Farruggia, P., Puccio, G., Locatelli, F., Vetro, M., Pillon, M., Trizzino, A., Sala, A., Buffardi, S., Garaventa, A., Rossi, F., Bianchi, M., Zecca, M., Pession, A., Favre, C., D’Amico, S., Provenzi, M., Zanazzo, G. A., Sau, A., Santoro, N., ... Burnelli, R. (2019). Classical pediatric Hodgkin lymphoma in very young patients: the Italian experience. LEUKEMIA & LYMPHOMA, 60, 696-702. https://doi.org/10.1080/10428194.2018.1493732

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title = "Classical pediatric Hodgkin lymphoma in very young patients: the Italian experience",

abstract = "Many studies have reported a more favorable outcome in younger patients with Hodgkin lymphoma (HL). The aims of this study were to find an appropriate age cutoff able to identify low-risk children and to describe the natural history of 135 very young patients affected by classic HL (cHL). The best age cutoff was identified at 7 years of age. EFS (p =.0451) and PFS (p =.00921) were significantly better in the group of younger patients. The OS rate at 10 years was 97.0% in the younger group and 92.5% in the older one (p =.0448). However, age was not found to be an independent prognostic factor in multivariate analysis and the better prognosis in younger patients seems to be related to more favorable disease characteristics at presentation.",

keywords = "chemotherapeutic approaches, pediatric, Lymphoma and Hodgkin disease, chemotherapeutic approaches, pediatric, Lymphoma and Hodgkin disease",

author = "Piero Farruggia and Giuseppe Puccio and Franco Locatelli and Mariarita Vetro and Marta Pillon and Angela Trizzino and Alessandra Sala and Salvatore Buffardi and Alberto Garaventa and Francesca Rossi and Maurizio Bianchi and Marco Zecca and Andrea Pession and Claudio Favre and Salvatore D{\textquoteright}Amico and Massimo Provenzi and Zanazzo, {Giulio Andrea} and Antonella Sau and Nicola Santoro and Rosamaria Mura and Caterina Elia and Tommaso Casini and Maurizio Mascarin and Roberta Burnelli",

year = "2019",

doi = "10.1080/10428194.2018.1493732",

language = "English",

volume = "60",

pages = "696--702",

journal = "LEUKEMIA & LYMPHOMA",

issn = "1042-8194",

publisher = "Taylor & Francis Limited:Rankine Road, Basingstoke RG24 8PR United Kingdom:011 44 1256 813035, EMAIL: [email protected], [email protected], INTERNET: http://www.tandf.co.uk, Fax: 011 44 1256 330245",

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Farruggia, P, Puccio, G, Locatelli, F, Vetro, M, Pillon, M, Trizzino, A, Sala, A, Buffardi, S, Garaventa, A, Rossi, F, Bianchi, M, Zecca, M, Pession, A, Favre, C, D’Amico, S, Provenzi, M, Zanazzo, GA, Sau, A, Santoro, N, Mura, R, Elia, C, Casini, T, Mascarin, M & Burnelli, R 2019, 'Classical pediatric Hodgkin lymphoma in very young patients: the Italian experience', LEUKEMIA & LYMPHOMA, vol. 60, pagg. 696-702. https://doi.org/10.1080/10428194.2018.1493732

TY - JOUR

T1 - Classical pediatric Hodgkin lymphoma in very young patients: the Italian experience

AU - Farruggia, Piero

AU - Puccio, Giuseppe

AU - Locatelli, Franco

AU - Vetro, Mariarita

AU - Pillon, Marta

AU - Trizzino, Angela

AU - Sala, Alessandra

AU - Buffardi, Salvatore

AU - Garaventa, Alberto

AU - Rossi, Francesca

AU - Bianchi, Maurizio

AU - Zecca, Marco

AU - Pession, Andrea

AU - Favre, Claudio

AU - D’Amico, Salvatore

AU - Provenzi, Massimo

AU - Zanazzo, Giulio Andrea

AU - Sau, Antonella

AU - Santoro, Nicola

AU - Mura, Rosamaria

AU - Elia, Caterina

AU - Casini, Tommaso

AU - Mascarin, Maurizio

AU - Burnelli, Roberta

PY - 2019

Y1 - 2019

N2 - Many studies have reported a more favorable outcome in younger patients with Hodgkin lymphoma (HL). The aims of this study were to find an appropriate age cutoff able to identify low-risk children and to describe the natural history of 135 very young patients affected by classic HL (cHL). The best age cutoff was identified at 7 years of age. EFS (p =.0451) and PFS (p =.00921) were significantly better in the group of younger patients. The OS rate at 10 years was 97.0% in the younger group and 92.5% in the older one (p =.0448). However, age was not found to be an independent prognostic factor in multivariate analysis and the better prognosis in younger patients seems to be related to more favorable disease characteristics at presentation.

AB - Many studies have reported a more favorable outcome in younger patients with Hodgkin lymphoma (HL). The aims of this study were to find an appropriate age cutoff able to identify low-risk children and to describe the natural history of 135 very young patients affected by classic HL (cHL). The best age cutoff was identified at 7 years of age. EFS (p =.0451) and PFS (p =.00921) were significantly better in the group of younger patients. The OS rate at 10 years was 97.0% in the younger group and 92.5% in the older one (p =.0448). However, age was not found to be an independent prognostic factor in multivariate analysis and the better prognosis in younger patients seems to be related to more favorable disease characteristics at presentation.

KW - chemotherapeutic approaches

KW - pediatric

KW - Lymphoma and Hodgkin disease

KW - chemotherapeutic approaches

KW - pediatric

KW - Lymphoma and Hodgkin disease

UR - http://hdl.handle.net/10807/229740

U2 - 10.1080/10428194.2018.1493732

DO - 10.1080/10428194.2018.1493732

M3 - Article

SN - 1042-8194

VL - 60

SP - 696

EP - 702

JO - LEUKEMIA & LYMPHOMA

JF - LEUKEMIA & LYMPHOMA

ER -

Classical pediatric Hodgkin lymphoma in very young patients: the Italian experience

Abstract

Keywords

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