Class III beta-Tubulin (TUBB3): More than a Biomarker in Solid Tumors?

Giovanni Scambia, M Mariani, S Shahabi, S Sieber, C. Ferlini

Risultato della ricerca: Contributo in rivistaArticolo in rivista

29 Citazioni (Scopus)

Abstract

Class III β-tubulin (TUBB3) is a prominent mechanism of drug resistance expressed in a variety of solid tumors and particularly in lung and ovarian cancer. In the classical view, TUBB3 expression and drug resistance have been linked, and together they have been associated with a perturbation in microtubule dynamics. In keeping with this observation, TUBB3 was associated with drug resistance only when chemotherapy included a taxane in its chemical composition. In this review, we demonstrate that the classical supposition about TUBB3 is not correct, and that instead TUBB3 expression is linked to drug resistance as a complex survival mechanism activated by microenvironmental conditions such as poor nutrient supply and hypoxia.
Lingua originaleEnglish
pagine (da-a)726-731
Numero di pagine6
RivistaCurrent Molecular Medicine
Volume11
Stato di pubblicazionePubblicato - 2011

Keywords

  • ovarian cancer

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