Class III β-tubulin (TUBB3): more than a biomarker in solid tumors?

Giovanni Scambia, Marisa Mariani, Cristiano Ferlini, S Shahabi, S Sieber

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Class III β-tubulin (TUBB3) is a prominent mechanism of drug resistance expressed in a variety of solid tumors and particularly in lung and ovarian cancer. In the classical view, TUBB3 expression and drug resistance have been linked, and together they have been associated with a perturbation in microtubule dynamics. In keeping with this observation, TUBB3 was associated with drug resistance only when chemotherapy included a taxane in its chemical composition. In this review, we demonstrate that the classical supposition about TUBB3 is not correct, and that instead TUBB3 expression is linked to drug resistance as a complex survival mechanism activated by microenvironmental conditions such as poor nutrient supply and hypoxia.
Lingua originaleEnglish
pagine (da-a)726-731
Numero di pagine6
RivistaCurrent Molecular Medicine
Volume11
Stato di pubblicazionePubblicato - 2011

Keywords

  • Animals
  • Cell Hypoxia
  • Drug Resistance, Neoplasm
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Hypoglycemia
  • Neoplasms
  • Tubulin
  • Tumor Markers, Biological

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