Class III β-tubulin (TUBB3) is a prominent mechanism of drug resistance expressed in a variety of solid tumors and particularly in lung and ovarian cancer. In the classical view, TUBB3 expression and drug resistance have been linked, and together they have been associated with a perturbation in microtubule dynamics. In keeping with this observation, TUBB3 was associated with drug resistance only when chemotherapy included a taxane in its chemical composition. In this review, we demonstrate that the classical supposition about TUBB3 is not correct, and that instead TUBB3 expression is linked to drug resistance as a complex survival mechanism activated by microenvironmental conditions such as poor nutrient supply and hypoxia.
|Numero di pagine||6|
|Rivista||Current Molecular Medicine|
|Stato di pubblicazione||Pubblicato - 2011|
- Cell Hypoxia
- Drug Resistance, Neoplasm
- Gene Expression Regulation, Neoplastic
- Tumor Markers, Biological