CL(-) and F(-) anions regulate the architecture of protofibrils in fibrin gel

Massimiliano Papi, Giuseppe Maulucci, Marco De Spirito, Mauro Missori, Giuseppe Arcovito

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

9 Citazioni (Scopus)

Abstract

Ischemic heart disease is the leading cause of serious morbidity and mortality in Western society. One of the therapeutic approaches is based on the use of thrombolitic drugs that promote clot lysis. Even if the mechanisms leading to clot lysis are not completely understood, it is widely accepted that they depend on the complex biochemical reactions that occur among fibrin fibers and fibrinolitic agents, and by their ready diffusion into the fibers. Here we investigate the effects of specific anions on the architecture of protofibrils within fibrin fibers in fibrin gels prepared in a para-physiological solution. The results obtained through small-angle X-ray scattering (SAXS) demonstrate that the characteristic axial and longitudinal repeat distances among protofibrils are strongly affected by the action of Cl- and F- anions.
Lingua originaleEnglish
pagine (da-a)1001-1006
Numero di pagine6
RivistaEUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
Volume2009
Stato di pubblicazionePubblicato - 2010

Keywords

  • X scattering
  • fibrin

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