CKD Prevalence Varies across the European General Population

Pietro Manuel Ferraro, Giovanni Gambaro, Katharina Brück, Vianda S. Stel, Stein Hallan, Henry Völzke, Johan Ärnlöv, Mika Kastarinen, Idris Guessous, José Vinhas, Bénédicte Stengel, Hermann Brenner, Jerzy Chudek, Solfrid Romundstad, Charles Tomson, Alfonso Otero Gonzalez, Aminu K. Bello, Jean Ferrieres, Luigi Palmieri, Gemma BrowneVincenzo Capuano, Wim Van Biesen, Carmine Zoccali, Ron Gansevoort, Gerjan Navis, Dietrich Rothenbacher, Dorothea Nitsch, Christoph Wanner, Kitty J. Jager

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

221 Citazioni (Scopus)

Abstract

CKD prevalence estimation is central to CKD management and prevention planning at the population level. This study estimated CKD prevalence in the European adult general population and investigated international variation in CKD prevalence by age, sex, and presence of diabetes, hypertension, and obesity. We collected data from 19 general-population studies from 13 European countries. CKD stages 1-5 was defined as eGFR<60 ml/min per 1.73 m(2), as calculated by the CKD-Epidemiology Collaboration equation, or albuminuria >30 mg/g, and CKD stages 3-5 was defined as eGFR<60 ml/min per 1.73 m(2). CKD prevalence was age- and sex-standardized to the population of the 27 Member States of the European Union (EU27). We found considerable differences in both CKD stages 1-5 and CKD stages 3-5 prevalence across European study populations. The adjusted CKD stages 1-5 prevalence varied between 3.31% (95% confidence interval [95% CI], 3.30% to 3.33%) in Norway and 17.3% (95% CI, 16.5% to 18.1%) in northeast Germany. The adjusted CKD stages 3-5 prevalence varied between 1.0% (95% CI, 0.7% to 1.3%) in central Italy and 5.9% (95% CI, 5.2% to 6.6%) in northeast Germany. The variation in CKD prevalence stratified by diabetes, hypertension, and obesity status followed the same pattern as the overall prevalence. In conclusion, this large-scale attempt to carefully characterize CKD prevalence in Europe identified substantial variation in CKD prevalence that appears to be due to factors other than the prevalence of diabetes, hypertension, and obesity.
Lingua originaleEnglish
pagine (da-a)2135-2147
Numero di pagine13
RivistaJOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
Volume27
DOI
Stato di pubblicazionePubblicato - 2015

Keywords

  • chronic kidney disease
  • clinical epidemiology
  • creatinine

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