Citrus fruit intake and gastric cancer: The stomach cancer pooling (StoP) project consortium

Paola Bertuccio, Gianfranco Alicandro, Matteo Rota, Claudio Pelucchi, Rossella Bonzi, Carlotta Galeone, Francesca Bravi, Kenneth C. Johnson, Jinfu Hu, Domenico Palli, Monica Ferraroni, Lizbeth López-Carrillo, Nuno Lunet, Ana Ferro, Reza Malekzadeh, David Zaridze, Dmitry Maximovitch, Jesus Vioque, Eva M. Navarrete-Munoz, Mohammadreza PaksereshtRaúl U. Hernández-Ramírez, Malaquias López-Cervantes, Mary Ward, Farhad Pourfarzi, Shoichiro Tsugane, Akihisa Hidaka, Zuo-Feng Zhang, Robert C. Kurtz, Pagona Lagiou, Areti Lagiou, Paolo Boffetta, Stefania Boccia, Eva Negri, Carlo La Vecchia

Risultato della ricerca: Contributo in rivistaArticolo in rivista

7 Citazioni (Scopus)


Diets rich in vegetables and fruit have been associated with reduced risk of gastric cancer, and there is suggestive evidence that citrus fruits have a protective role. Our study aimed at evaluating and quantifying the association between citrus fruit intake and gastric cancer risk. We conducted a one-stage pooled analysis including 6,340 cases and 14,490 controls from 15 case-control studies from the stomach cancer pooling (StoP) project consortium. Odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) of gastric cancer across study-specific tertiles of citrus fruit intake (grams/week) were estimated by generalized linear mixed effect models, with logistic link function and random intercept for each study. The models were adjusted for sex, age, and the main recognized risk factors for gastric cancer. Compared to the first third of the distribution, the adjusted pooled OR (95% CI) for the highest third was 0.80 (0.73-0.87). The favourable effect of citrus fruits increased progressively until three servings/week and leveled off thereafter. The magnitude of the association was similar between cancer sub-sites and histotypes. The analysis by geographic area showed no association in studies from the Americas. Our data confirm an inverse association between citrus fruits and gastric cancer and provide precise estimates of the magnitude of the association. However, the null association found in studies from America and in some previous cohort studies prevent to draw definite conclusions on a protective effect of citrus fruit consumption.
Lingua originaleEnglish
pagine (da-a)2936-2944
Numero di pagine9
RivistaInternational Journal of Cancer
Stato di pubblicazionePubblicato - 2019


  • Case-control studies
  • Stomach Neoplasms
  • citrus fruits
  • gastric cancer


Entra nei temi di ricerca di 'Citrus fruit intake and gastric cancer: The stomach cancer pooling (StoP) project consortium'. Insieme formano una fingerprint unica.

Cita questo