Cisplatin neuropathy: clinical course and neurophysiological findings

Luca Padua, Domenico Restuccia, Mauro Lo Monaco, Anna Paola Batocchi, Margherita Milone, Pietro Attilio Tonali

Risultato della ricerca: Contributo in rivistaArticolo in rivista

86 Citazioni (Scopus)

Abstract

Sixteen patients treated with cisplatin (CDDP) 40 mg/m2 on days 1-5 every 4 weeks for three courses (cumulative dose 600 mg/m2) were clinically and neurophysiologically tested before, during and 1, 3, 6, 9 and 12 months after CDDP administration. The first symptoms of polyneuropathy occurred in 4 of 9 patients after the second course (cumulative dose 400 mg/m2). One month after treatment 1 of 9 patients was asymptomatic, 5 complained of symptoms and 3 showed clinical and neurophysiological signs of polyneuropathy. Three months after CDDP all patients were affected. Clinical and neurophysiological signs of severity progression were noted up to 6 months after treatment with CDDP
Lingua originaleEnglish
pagine (da-a)199-204
Numero di pagine6
RivistaJournal of Neurology
Volume1992
Stato di pubblicazionePubblicato - 1992

Keywords

  • cisplatin
  • neuropathy
  • neurophysiological findings

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