CIRCULATING PLACENTAL VESCICLES CARRY HLA-DR IN PRE - ECLAMPSIA : A NEW POTENTIAL MARKER OF THE SYNDROME

Donatella Lucchetti, Alessandro Sgambato, Antonio Lanzone, Giovanni Scambia, Chiara Tersigni, Rita Franco, Filomena Colella, Caterina Neri, Nicoletta Di Simone, L CRISPINO, M VATISH

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

Abstract

Pre-eclampsia (PE) is a common disorder of pregnancy that usually presents with hypertension and proteinuria. The clinical presentation arises from soluble factors released into the maternal circulation from the placenta owing to the stress of syncytiotrophoblast, consequence of defective placentation occurring in the first half of pregnancy. Reduced tolerance of the semiallogeneic fetus by the maternal immune system has been proposed as first trigger leading to poor placentation. We previously observed aberrant expression of human leukocyte antigen (HLA)-DR molecules in the syncytiotrophoblast of a subset of women with PE. Aim of this study was to investigate abnormal expression of circulating HLA-DR in syncytiotrophoblast-derived extracellular vesicles (STBEVs) in women with PE compared to normal pregnant women.
Lingua originaleEnglish
pagine (da-a)1-6
Numero di pagine6
RivistaFrontiers in Immunology
Stato di pubblicazionePubblicato - 2021

Keywords

  • human leukocyte antigen

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