Circulating Mitochondrial DNA at the Crossroads of Mitochondrial Dysfunction and Inflammation During Aging and Muscle Wasting Disorders

Maurizio Bossola, Francesco Landi, Roberto Bernabei, Emanuele Marzetti, Riccardo Calvani, Angela Maria Serena Lezza, Christiaan Leeuwenburgh, Vito Pesce

Risultato della ricerca: Contributo in rivistaArticolo in rivista

44 Citazioni (Scopus)

Abstract

Mitochondrial structural and functional integrity is maintained through the coordination of several processes (e.g., biogenesis, dynamics, mitophagy), collectively referred to as mitochondrial quality control (MQC). Dysfunctional MQC and inflammation are hallmarks of aging and are involved in the pathogenesis of muscle wasting disorders, including sarcopenia and cachexia. One of the consequences of failing MQC is the release of mitochondria-derived damage-associated molecular patterns (DAMPs). By virtue of their bacterial ancestry, these molecules can trigger an inflammatory response by interacting with receptors similar to those involved in pathogen-associated responses. Mitochondria-derived DAMPs, especially cell-free mitochondrial DNA, have recently been associated with conditions characterized by chronic inflammation, such as aging and degenerative diseases. Yet, their actual implication in the aging process and muscle wasting disorders is at an early stage of investigation. Here, we review the contribution of mitochondria-derived DAMPs to age-related systemic inflammation. We also provide arguments in support of the exploitation of such signaling pathways for the management of muscle wasting conditions.
Lingua originaleEnglish
pagine (da-a)350-359
Numero di pagine10
RivistaRejuvenation Research
Volume21
DOI
Stato di pubblicazionePubblicato - 2018

Keywords

  • Aging
  • Animals
  • DAMPs
  • DNA, Mitochondrial
  • Humans
  • Inflammation
  • Mitochondria
  • Oxidative Stress
  • Sarcopenia
  • autophagy
  • cachexia
  • mitochondrial biogenesis
  • mitochondrial quality control
  • sarcopenia

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