Circulating endothelial cells as marker of endothelial damage in male hypogonadism

Alfredo Pontecorvi, Domenico Milardi, Giuseppe Grande, Antonella Giampietro, Francesca Vendittelli, Sara Palumbo, Linda Tartaglione, Riccardo Marana, Laura De Marinis Grasso, Cecilia Zuppi, Ettore Domenico Capoluongo

Risultato della ricerca: Contributo in rivistaArticolo in rivista

4 Citazioni (Scopus)

Abstract

Testosterone deficiency has become a frequently diagnosed condition in today's society affected by epidemic obesity, and is associated with cardiovascular risk. Recent studies have established the importance of altered vascular endothelium function in cardiovascular disease. The damage to the endothelium might also cause endothelial cell detachment, resulting in increased numbers of circulating endothelial cells (CEC) within the bloodstream. To evaluate whether hypogonadism could modify CEC count in peripheral bloodstream, we investigated peripheral blood CEC count using the CellSearch System, a semiautomatic method to accurately and reliably enumerate CECs, which are sorted based on a CD146(+), CD105(+), DAPI(+), CD45(-) phenotype, in a population of 20 patients with hypogonadism. The control group comprised 10 age- and sex-matched healthy participants. CEC count per milliliter was significantly increased in patients with hypogonadism vs the control group. In the group with hypogonadism, an inverse exponential correlation was present between testosterone levels and CEC count per milliliter. A direct linear correlation was present between waist circumference and CECs and between body mass index and CECs. The regression analysis showed that testosterone was the significant independent determinant of CECs. Our results underline that male hypogonadism is associated with endothelial dysfunction. The correlation between CEC and waist circumference underlines that visceral obesity may be synergically implicated in this regulation. Future studies are required to unveil the mechanisms involved in the pathogenesis of testosterone-induced endothelial disfunction, which may provide novel therapeutic targets to be incorporated in the management of hypogonadism.
Lingua originaleEnglish
pagine (da-a)1291-1297
Numero di pagine7
RivistaJournal of Andrology
Volume33
DOI
Stato di pubblicazionePubblicato - 2012

Keywords

  • Adult
  • Endothelial Cells
  • Endothelium, Vascular
  • Humans
  • Hypogonadism
  • Male
  • Middle Aged
  • Neoplastic Cells, Circulating
  • Obesity
  • Testosterone
  • Vascular Diseases

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