Circulating CD8+CD56-Perforin+ T cells are increased in Multiple Sclerosis patients

Giovanni Frisullo; Domenico Plantone; Alessandro Marti; Raffaele Iorio; Viviana Nociti; Agata Katia Patanella; Anna Paola Batocchi

Circulating CD8+CD56-Perforin+ T cells are increased in Multiple Sclerosis patients

Giovanni Frisullo
, Domenico Plantone
, Alessandro Marti
, Raffaele Iorio
, Viviana Nociti
, Agata Katia Patanella
, Anna Paola Batocchi

Risultato della ricerca: Contributo in rivista › Articolo › peer review

Abstract

Relapsing-remitting multiple sclerosis (RRMS), secondary progressive (SP)MS and primary progressive (PP)MS patients showed higher percentages of circulating CD8+CD56-perforin+ T cells than controls whereas only relapsing RRMS and PPMS patients showed higher perforin expression in CD8+CD56- T cells than controls. MS patients with EDSS ≥3 showed higher percentage of CD8+CD56-perforin+ T cells than patients with EDSS <3 and controls whereas patients with EDSS <3 showed higher percentage of this T cell subpopulation than controls. Our data show that MS is characterized by a dysregulation of CD8+CD56-perforin+ T cells that may play a role in the development of disability.

Lingua originale	Inglese
pagine (da-a)	137-141
Numero di pagine	5
Rivista	Journal of Neuroimmunology
Volume	2011
Stato di pubblicazione	Pubblicato - 2011

Keywords

multiple sclerosis

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title = "Circulating CD8+CD56-Perforin+ T cells are increased in Multiple Sclerosis patients",

abstract = "Relapsing-remitting multiple sclerosis (RRMS), secondary progressive (SP)MS and primary progressive (PP)MS patients showed higher percentages of circulating CD8+CD56-perforin+ T cells than controls whereas only relapsing RRMS and PPMS patients showed higher perforin expression in CD8+CD56- T cells than controls. MS patients with EDSS ≥3 showed higher percentage of CD8+CD56-perforin+ T cells than patients with EDSS <3 and controls whereas patients with EDSS <3 showed higher percentage of this T cell subpopulation than controls. Our data show that MS is characterized by a dysregulation of CD8+CD56-perforin+ T cells that may play a role in the development of disability.",

keywords = "multiple sclerosis, multiple sclerosis",

author = "Giovanni Frisullo and Domenico Plantone and Alessandro Marti and Raffaele Iorio and Viviana Nociti and Patanella, \{Agata Katia\} and Batocchi, \{Anna Paola\}",

year = "2011",

language = "English",

volume = "2011",

pages = "137--141",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Circulating CD8+CD56-Perforin+ T cells are increased in Multiple Sclerosis patients

AU - Frisullo, Giovanni

AU - Plantone, Domenico

AU - Marti, Alessandro

AU - Iorio, Raffaele

AU - Nociti, Viviana

AU - Patanella, Agata Katia

AU - Batocchi, Anna Paola

PY - 2011

Y1 - 2011

N2 - Relapsing-remitting multiple sclerosis (RRMS), secondary progressive (SP)MS and primary progressive (PP)MS patients showed higher percentages of circulating CD8+CD56-perforin+ T cells than controls whereas only relapsing RRMS and PPMS patients showed higher perforin expression in CD8+CD56- T cells than controls. MS patients with EDSS ≥3 showed higher percentage of CD8+CD56-perforin+ T cells than patients with EDSS <3 and controls whereas patients with EDSS <3 showed higher percentage of this T cell subpopulation than controls. Our data show that MS is characterized by a dysregulation of CD8+CD56-perforin+ T cells that may play a role in the development of disability.

AB - Relapsing-remitting multiple sclerosis (RRMS), secondary progressive (SP)MS and primary progressive (PP)MS patients showed higher percentages of circulating CD8+CD56-perforin+ T cells than controls whereas only relapsing RRMS and PPMS patients showed higher perforin expression in CD8+CD56- T cells than controls. MS patients with EDSS ≥3 showed higher percentage of CD8+CD56-perforin+ T cells than patients with EDSS <3 and controls whereas patients with EDSS <3 showed higher percentage of this T cell subpopulation than controls. Our data show that MS is characterized by a dysregulation of CD8+CD56-perforin+ T cells that may play a role in the development of disability.

KW - multiple sclerosis

UR - http://hdl.handle.net/10807/7772

M3 - Article

SN - 0165-5728

VL - 2011

SP - 137

EP - 141

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

ER -

Circulating CD8+CD56-Perforin+ T cells are increased in Multiple Sclerosis patients

Abstract

Keywords

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