Circulating CD56dim NK cells expressing perforin are increased in progressive multiple sclerosis

Domenico Plantone; Alessandro Marti; Giovanni Frisullo; Raffaele Iorio; Valentina Damato; Viviana Nociti; Agata Katia Patanella; Assunta Bianco; Massimiliano Mirabella; Anna Paola Batocchi

doi:10.1016/j.jneuroim.2013.10.004

Circulating CD56dim NK cells expressing perforin are increased in progressive multiple sclerosis

Domenico Plantone^*
, Alessandro Marti
, Giovanni Frisullo
, Raffaele Iorio
, Valentina Damato
, Viviana Nociti
, Agata Katia Patanella
, Assunta Bianco
, Massimiliano Mirabella
, Anna Paola Batocchi

^*Autore corrispondente per questo lavoro

IRCCS Fondazione Don Carlo Gnocchi - Milano

Risultato della ricerca: Contributo in rivista › Articolo › peer review

13 Citazioni (Scopus)

Abstract

In this study we evaluated the percentages of CD3(-)CD56(bright), CD3(-)CD56(dim), CD3(-)CD56(bright)perforin(+) and CD3(-)CD56(dim)perforin(+) Natural Killer (NK) cells in peripheral blood from untreated secondary progressive (SP) and primary progressive (PP) multiple sclerosis (MS) patients and age and sex matched healthy subjects. Both PPMS patients and SPMS patients showed increased percentages of circulating CD3(-)CD56(dim)perforin(+) NK cells than healthy subjects. The increased percentage of CD3(-)CD56(dim) NK cells expressing perforin in patients affected by the progressive forms of MS suggests a possible role of this NK cell subpopulation in the pathogenesis of the disease.

Lingua originale	Inglese
pagine (da-a)	124-127
Numero di pagine	4
Rivista	Journal of Neuroimmunology
Volume	265
Numero di pubblicazione	1-2
DOI	https://doi.org/10.1016/j.jneuroim.2013.10.004
Stato di pubblicazione	Pubblicato - 2013

All Science Journal Classification (ASJC) codes

Immunologia e Allergia
Immunologia
Neurologia
Neurologia (clinica)

Keywords

Adult
Aged
Analysis of Variance
Antigens
CD56
Case-Control Studies
Chronic Progressive
Cytotoxicity
Disability Evaluation
Female
Flow Cytometry
Humans
Killer Cells
Male
Middle Aged
Multiple Sclerosis
Natural
Natural Killer cells
Perforin
Progressive multiple sclerosis

Accesso al documento

10.1016/j.jneuroim.2013.10.004

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title = "Circulating CD56dim NK cells expressing perforin are increased in progressive multiple sclerosis",

abstract = "In this study we evaluated the percentages of CD3(-)CD56(bright), CD3(-)CD56(dim), CD3(-)CD56(bright)perforin(+) and CD3(-)CD56(dim)perforin(+) Natural Killer (NK) cells in peripheral blood from untreated secondary progressive (SP) and primary progressive (PP) multiple sclerosis (MS) patients and age and sex matched healthy subjects. Both PPMS patients and SPMS patients showed increased percentages of circulating CD3(-)CD56(dim)perforin(+) NK cells than healthy subjects. The increased percentage of CD3(-)CD56(dim) NK cells expressing perforin in patients affected by the progressive forms of MS suggests a possible role of this NK cell subpopulation in the pathogenesis of the disease.",

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author = "Domenico Plantone and Alessandro Marti and Giovanni Frisullo and Raffaele Iorio and Valentina Damato and Viviana Nociti and Patanella, \{Agata Katia\} and Assunta Bianco and Massimiliano Mirabella and Batocchi, \{Anna Paola\}",

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T1 - Circulating CD56dim NK cells expressing perforin are increased in progressive multiple sclerosis

AU - Plantone, Domenico

AU - Marti, Alessandro

AU - Frisullo, Giovanni

AU - Iorio, Raffaele

AU - Damato, Valentina

AU - Nociti, Viviana

AU - Patanella, Agata Katia

AU - Bianco, Assunta

AU - Mirabella, Massimiliano

AU - Batocchi, Anna Paola

PY - 2013

Y1 - 2013

N2 - In this study we evaluated the percentages of CD3(-)CD56(bright), CD3(-)CD56(dim), CD3(-)CD56(bright)perforin(+) and CD3(-)CD56(dim)perforin(+) Natural Killer (NK) cells in peripheral blood from untreated secondary progressive (SP) and primary progressive (PP) multiple sclerosis (MS) patients and age and sex matched healthy subjects. Both PPMS patients and SPMS patients showed increased percentages of circulating CD3(-)CD56(dim)perforin(+) NK cells than healthy subjects. The increased percentage of CD3(-)CD56(dim) NK cells expressing perforin in patients affected by the progressive forms of MS suggests a possible role of this NK cell subpopulation in the pathogenesis of the disease.

AB - In this study we evaluated the percentages of CD3(-)CD56(bright), CD3(-)CD56(dim), CD3(-)CD56(bright)perforin(+) and CD3(-)CD56(dim)perforin(+) Natural Killer (NK) cells in peripheral blood from untreated secondary progressive (SP) and primary progressive (PP) multiple sclerosis (MS) patients and age and sex matched healthy subjects. Both PPMS patients and SPMS patients showed increased percentages of circulating CD3(-)CD56(dim)perforin(+) NK cells than healthy subjects. The increased percentage of CD3(-)CD56(dim) NK cells expressing perforin in patients affected by the progressive forms of MS suggests a possible role of this NK cell subpopulation in the pathogenesis of the disease.

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ER -

Circulating CD56dim NK cells expressing perforin are increased in progressive multiple sclerosis

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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