Circulating CD56dim NK cells expressing perforin are increased in progressive multiple sclerosis

Massimiliano Mirabella, Domenico Plantone, Alessandro Marti, Giovanni Frisullo, Raffaele Iorio, Valentina Damato, Viviana Nociti, Agata Katia Patanella, Assunta Bianco, Anna Paola Batocchi

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

11 Citazioni (Scopus)

Abstract

In this study we evaluated the percentages of CD3(-)CD56(bright), CD3(-)CD56(dim), CD3(-)CD56(bright)perforin(+) and CD3(-)CD56(dim)perforin(+) Natural Killer (NK) cells in peripheral blood from untreated secondary progressive (SP) and primary progressive (PP) multiple sclerosis (MS) patients and age and sex matched healthy subjects. Both PPMS patients and SPMS patients showed increased percentages of circulating CD3(-)CD56(dim)perforin(+) NK cells than healthy subjects. The increased percentage of CD3(-)CD56(dim) NK cells expressing perforin in patients affected by the progressive forms of MS suggests a possible role of this NK cell subpopulation in the pathogenesis of the disease.
Lingua originaleEnglish
pagine (da-a)124-127
Numero di pagine4
RivistaJournal of Neuroimmunology
Volume265
DOI
Stato di pubblicazionePubblicato - 2013

Keywords

  • Adult
  • Aged
  • Analysis of Variance
  • Antigens, CD56
  • Case-Control Studies
  • Cytotoxicity
  • Disability Evaluation
  • Female
  • Flow Cytometry
  • Humans
  • Killer Cells, Natural
  • Male
  • Middle Aged
  • Multiple Sclerosis, Chronic Progressive
  • Natural Killer cells
  • Perforin
  • Progressive multiple sclerosis

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