Circular RNAs Activity in the Leukemic Bone Marrow Microenvironment

Francesca Liccardo, Alessia Iaiza, Martyna Śniegocka, Silvia Masciarelli, Francesco Fazi

Risultato della ricerca: Contributo in rivistaArticolo in rivista


Acute myeloid leukemia (AML) is a hematological malignancy originating from defective hematopoietic stem cells in the bone marrow. In spite of the recent approval of several molecular targeted therapies for AML treatment, disease recurrence remains an issue. Interestingly, increasing evidence has pointed out the relevance of bone marrow (BM) niche remodeling during leukemia onset and progression. Complex crosstalk between AML cells and microenvironment components shapes the leukemic BM niche, consequently affecting therapy responsiveness. Notably, circular RNAs are a new class of RNAs found to be relevant in AML progression and chemoresistance. In this review, we provided an overview of AML-driven niche remodeling. In particular, we analyzed the role of circRNAs and their possible contribution to cell–cell communication within the leukemic BM microenvironment. Understanding these mechanisms will help develop a more effective treatment for AML.
Lingua originaleEnglish
pagine (da-a)50-63
Numero di pagine14
RivistaNon-coding RNA
Stato di pubblicazionePubblicato - 2022


  • acute myeloid leukemia
  • bone marrow niche
  • circRNA
  • hematopoietic stem cell
  • non-coding RNA
  • therapy resistance
  • tumor microenvironment


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