Cigarette, Cigar, and Pipe Smoking and the Risk of Head and Neck Cancers: Pooled Analysis in the International Head and Neck Cancer Epidemiology Consortium

Gabriella Cadoni, Stefania Boccia, Annah Wyss, Mia Hashibe, Shu-Chun Chuang, Yuan-Chin Amy Lee, Zuo-Feng Zhang, Guo-Pei Yu, Deborah M. Winn, Qingyi Wei, Erich M. Sturgis, Renato Talamini, Luigino Dal Maso, Neonila Szeszenia-Dabrowska, Elaine Smith, Oxana Shangina, Stephen M Schwartz, Chu Chen, Stimson Schantz, Peter RudnaiMark P. Purdue, Jose Eluf-Neto, Joshua Muscat, Hal Morgenstern, Pedro Michaluart Jr., Ana Menezes, Elena Matos, Ioan Nicolae Mates, Jolanta Lissowska, Fabio Levi, Philip Lazarus, Carlo La Vecchia, Sergio Koifman, Rolando Herrero, Richard B. Hayes, Silvia Franceschi, Victor Wünsch-Filho, Leticia Fernandez, Eleonora Fabianova, Alexander W. Daudt, Maria Paula Curado, Paolo Boffetta, Xavier Castellsague, Marcos Brasilino De Carvalho, Paul Brennan, Andrew F. Olshan

Risultato della ricerca: Contributo in rivistaArticolo in rivista

133 Citazioni (Scopus)

Abstract

Cigar and pipe smoking are considered risk factors for head and neck cancers, but the magnitude of effect estimates for these products has been imprecisely estimated. By using pooled data from the International Head and Neck Cancer Epidemiology (INHANCE) Consortium (comprising 13,935 cases and 18,691 controls in 19 studies from 1981 to 2007), we applied hierarchical logistic regression to more precisely estimate odds ratios and 95% confidence intervals for cigarette, cigar, and pipe smoking separately, compared with reference groups of those who had never smoked each single product. Odds ratios for cigar and pipe smoking were stratified by ever cigarette smoking. We also considered effect estimates of smoking a single product exclusively versus never having smoked any product (reference group). Among never cigarette smokers, the odds ratio for ever cigar smoking was 2.54 (95% confidence interval (CI): 1.93, 3.34), and the odds ratio for ever pipe smoking was 2.08 (95% CI: 1.55, 2.81). These odds ratios increased with increasing frequency and duration of smoking (Ptrend ≤ 0.0001). Odds ratios for cigar and pipe smoking were not elevated among ever cigarette smokers. Head and neck cancer risk was elevated for those who reported exclusive cigar smoking (odds ratio = 3.49, 95% CI: 2.58, 4.73) or exclusive pipe smoking (odds ratio = 3.71, 95% CI: 2.59, 5.33). These results suggest that cigar and pipe smoking are independently associated with increased risk of head and neck cancers
Lingua originaleEnglish
pagine (da-a)679-690
Numero di pagine12
RivistaAmerican Journal of Epidemiology
Volume178
DOI
Stato di pubblicazionePubblicato - 2013

Keywords

  • head and neck neoplasms
  • smoking

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