Chronic rhinosinusitis with nasal polyps impact in severe asthma patients: Evidences from the Severe Asthma Network Italy (SANI) registry

Paolo Montuschi, Eleonora Nucera, Luca Richeldi, Silvia D'Alonzo, Gabriella Macchia, Giovanna Marolla, Giorgio Walter Canonica, Luca Malvezzi, Francesco Blasi, Pierluigi Paggiaro, Marco Mantero, Gianenrico Senna, Enrico Heffler, M. Bonavia, P. Caiaffa, C. Calabrese, G. Camiciottoli, C. Caruso, S. Centanni, M. E. ConteA. G. Corsico, L. Cosmi, M. T. Costantino, N. Crimi, S. D'Alò, M. D'Amato, S. Del Giacco, E. Favero, A. Farsi, B. P.M. Foschino, G. Guarnieri, G. Guida, M. Latorre, C. Lombardi, L. Macchia, F. Menzella, M. Milanese, R. Parente, G. Passalacqua, V. Patella, G. Pelaia, L. Pini, F. L.M. Ricciardolo, L. Ricciardi, E. Ridolo, G. Rolla, P. Santus, N. Scichilone, P. Solidoro, G. Spadaro, A. Spanevello, A. Vianello, M. R. Yacoub, M. C. Zappa

Risultato della ricerca: Contributo in rivistaArticolo in rivista

10 Citazioni (Scopus)

Abstract

Background: The clinical and laboratory features of patients enrolled in the Severe Asthma Network in Italy (SANI) registry, a web-based observatory collecting demographic, clinical, functional and inflammatory data of patients with severe asthma were evaluated, with a special emphasis to chronic rhinosinusitis with nasal polyposis (CRSwNP). Methods: For each eligible patients the following information has been collected: demographic data, clinical features, asthma control in the previous month according to the GINA (Global INitiative for Asthma) Guidelines and standardized questionnaires, concomitant regular and on demand treatments and inflammatory markers. Results: 695 patients with severe asthma enrolled in 66 SANI centers were analyzed. The prevalence of chronic rhinosinusitis with nasal polyposis was 40.6%. Atopic dermatitis and bronchiectasis was significantly more frequent in patients with CRSwNP than in subjects without nasal polyposis; similarly, FeNO values are significantly higher in subject with CRSwNP than in patients without nasal polyposis. Finally, patients with CRSwNP had a significantly higher number of asthma exacerbations per year, more days on oral corticosteroids and were more likely to be OCS long term users. Conclusion: OCS sparing is needed in patients with severe asthma, mainly in subjects with CRSwNP, adopting adequate strategies such as a better adherence to the treatment with inhaled therapy according to the GINA recommendations, the use of biologic agents and a multidisciplinary approach of the patient.
Lingua originaleEnglish
pagine (da-a)105947-N/A
RivistaRespiratory Medicine
Volume166
DOI
Stato di pubblicazionePubblicato - 2020

Keywords

  • Comorbidities
  • Nasal polyps
  • Oral corticosteroids
  • Severe asthma

Fingerprint Entra nei temi di ricerca di 'Chronic rhinosinusitis with nasal polyps impact in severe asthma patients: Evidences from the Severe Asthma Network Italy (SANI) registry'. Insieme formano una fingerprint unica.

Cita questo