TY - JOUR
T1 - Chronic graft-versus-host disease in children: incidence, risk factors, and impact on outcome
AU - Zecca, Marco
AU - Prete, Arcangelo
AU - Rondelli, Roberto
AU - Lanino, Edoardo
AU - Balduzzi, Adriana
AU - Messina, Chiara
AU - Fagioli, Franca
AU - Porta, Fulvio
AU - Favre, Claudio
AU - Pession, Andrea
AU - Locatelli, Franco
PY - 2002
Y1 - 2002
N2 - Chronic graft-versus-host disease (cGVHD) remains the major cause of late morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT). However, only a few studies specifically focused on children, and little information is available on the antileukemic effect of cGVHD and Its Impact on disease-free survival (DFS) In children. We retrospectively analyzed 696 children given allogeneic HSCT for malignant (n = 450) or nonmalignant (n = 246) diseases. The donor was an HLA-identical sibling in 461 cases and an alternative donor in 235. Bone marrow was the stem cell source in 647 cases, peripheral blood In 17, and cord blood (CB) in 32. cGVHD developed in 173 children (25%) at a median of 116 days after HSCT Three-year cGVHD probability was 27%. In multivariate analysis, variables predicting cGVHD were donor and recipient age, grade 11 to IV acute GVHD, female donor for male recipient, diagnosis of malignancy, and use of total body Irradiation; CB transplants had a very low risk of cGVHD (RR = 0.079 P = .0001). cGVHD occurrence increased transplant-related mortality (P < .05). Nevertheless, in hematologic malignancies, patients with cGVHD had a reduced relapse probability compared with children without cGVHD (16% +/- 3% versus 39% +/- 3%, P = .0001) and a better DFS (68% +/- 4% versus 54% +/- 3%, P = .01). The antileukemic effect of cGVHD was observed mainly In patients with acute lymphoblastic leukemia (ALL). This study provides novel data on cGVHD in childhood. Use of CB stem cells and preparative regimens without radiotherapy may prevent Its development. In patients affected by ALL, cGVHD was associated with a strong graft-versus-leukemia effect, improving DFS. (C) 2002 by The American Society of Hematology.
AB - Chronic graft-versus-host disease (cGVHD) remains the major cause of late morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT). However, only a few studies specifically focused on children, and little information is available on the antileukemic effect of cGVHD and Its Impact on disease-free survival (DFS) In children. We retrospectively analyzed 696 children given allogeneic HSCT for malignant (n = 450) or nonmalignant (n = 246) diseases. The donor was an HLA-identical sibling in 461 cases and an alternative donor in 235. Bone marrow was the stem cell source in 647 cases, peripheral blood In 17, and cord blood (CB) in 32. cGVHD developed in 173 children (25%) at a median of 116 days after HSCT Three-year cGVHD probability was 27%. In multivariate analysis, variables predicting cGVHD were donor and recipient age, grade 11 to IV acute GVHD, female donor for male recipient, diagnosis of malignancy, and use of total body Irradiation; CB transplants had a very low risk of cGVHD (RR = 0.079 P = .0001). cGVHD occurrence increased transplant-related mortality (P < .05). Nevertheless, in hematologic malignancies, patients with cGVHD had a reduced relapse probability compared with children without cGVHD (16% +/- 3% versus 39% +/- 3%, P = .0001) and a better DFS (68% +/- 4% versus 54% +/- 3%, P = .01). The antileukemic effect of cGVHD was observed mainly In patients with acute lymphoblastic leukemia (ALL). This study provides novel data on cGVHD in childhood. Use of CB stem cells and preparative regimens without radiotherapy may prevent Its development. In patients affected by ALL, cGVHD was associated with a strong graft-versus-leukemia effect, improving DFS. (C) 2002 by The American Society of Hematology.
KW - Hematologic Diseases
KW - Hematologic Diseases
UR - http://hdl.handle.net/10807/262441
U2 - 10.1182/blood-2001-11-0059
DO - 10.1182/blood-2001-11-0059
M3 - Article
SN - 0006-4971
VL - 100
SP - 1192
EP - 1200
JO - Blood
JF - Blood
ER -