TY - JOUR
T1 - Chronic Asymptomatic Pancreatic Hyperenzymemia: A Long-term Follow-up
AU - Amodio, Antonio
AU - Amodio, Vito Antonio
AU - De Marchi, Giulia
AU - Granato, Anna
AU - De Pretis, Nicolò
AU - Gabbrielli, Armando
AU - Manfredi, Riccardo
AU - Pozzi Mucelli, Roberto
AU - Frulloni, Luca
PY - 2019
Y1 - 2019
N2 - Objectives:Chronicasymptomaticpancreatichyperenzymemia(CAPH) was describedas a benigndisease. However,we already describedclinically relevant findings requiring surgery or follow-up in half of the subjects. The aimofthisstudywastoevaluatethelong-termoutcomeofCAPHinterms of symptoms and evolution toward chronic pancreatitis. Methods: Subjects previously enrolled in the first phase of the study (from 2005 to 2010) were reinvestigated from December 2013 to January 2017withaphonecall±magneticresonancecholangiopancreatographywith secretin stimulation. Results:Atotalof133subjectswereeligibleforthefollow-upstudy(75males, 58 females; age, 48.4 [standard deviation {SD}, 14] years); 24 (18%) of them dropped out. During a mean follow-up of 9.3 (SD, 5.2) years after thefirstdiagnosisofCAPH,noepisodeofacutepancreatitisorabdominal pain was reported. Sixty-three subjects (58%) of 109 underwent magnetic resonance cholangiopancreatography with secretin stimulation with a mean follow-up of 5.7 [SD, 3.1] years (range, 1–11 years). Secretin stimulationMRCP resulted unchanged in 54 (90%) of 60 subjects, worsened in 3 (5%) and improved in 3 (5%). Two subjects died from causes unrelated to pancreatic disease. Conclusions:Excludingsubjectswithapancreaticdiseaseatindexmagnetic resonance imaging, CAPH is a benign condition.
AB - Objectives:Chronicasymptomaticpancreatichyperenzymemia(CAPH) was describedas a benigndisease. However,we already describedclinically relevant findings requiring surgery or follow-up in half of the subjects. The aimofthisstudywastoevaluatethelong-termoutcomeofCAPHinterms of symptoms and evolution toward chronic pancreatitis. Methods: Subjects previously enrolled in the first phase of the study (from 2005 to 2010) were reinvestigated from December 2013 to January 2017withaphonecall±magneticresonancecholangiopancreatographywith secretin stimulation. Results:Atotalof133subjectswereeligibleforthefollow-upstudy(75males, 58 females; age, 48.4 [standard deviation {SD}, 14] years); 24 (18%) of them dropped out. During a mean follow-up of 9.3 (SD, 5.2) years after thefirstdiagnosisofCAPH,noepisodeofacutepancreatitisorabdominal pain was reported. Sixty-three subjects (58%) of 109 underwent magnetic resonance cholangiopancreatography with secretin stimulation with a mean follow-up of 5.7 [SD, 3.1] years (range, 1–11 years). Secretin stimulationMRCP resulted unchanged in 54 (90%) of 60 subjects, worsened in 3 (5%) and improved in 3 (5%). Two subjects died from causes unrelated to pancreatic disease. Conclusions:Excludingsubjectswithapancreaticdiseaseatindexmagnetic resonance imaging, CAPH is a benign condition.
KW - inglese
KW - inglese
UR - http://hdl.handle.net/10807/135107
U2 - 10.1097/MPA.0000000000001272
DO - 10.1097/MPA.0000000000001272
M3 - Article
SN - 0885-3177
VL - 48
SP - 544
EP - 547
JO - Pancreas
JF - Pancreas
ER -