Chromosome 9q and 16q loss identified by genome-wide pooled-analysis are associated with tumor aggressiveness in patients with classic medulloblastoma

Riccardo Riccardi, Tiziana Servidei, Simona Coco, Francesca Valdora, Stefano Bonassi, Paola Scaruffi, Sara Stigliani, André Oberthuer, Frank Berthold, Immacolata Andolfo, Eleonora Basso, Achille Iolascon, Gian Paolo Tonini

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6 Citazioni (Scopus)

Abstract

Medulloblastoma (MB) is one of the most aggressive pediatric brain tumor. We report genome-wide pooled-analysis of classic MB variant of patients over 3 years of age at diagnosis. We combined array comparative genomic hybridization (aCGH) results from experimental analysis (31 cases) with two public databases (55 cases) in a final evaluation of 86 MBs. The most common chromosome structural aberrations were gains of 17q (45.3%), 1q (22.1%), and losses of 8p (15.1%), 10q (19.8%), 17p (37.2%), and 16q (16.3%). Isochromome (17q) was observed in 29.1% MBs. A significant association between poor patients survival and losses of 9q (p < 0.0023), 10q (p < 0.012), and 16q (p < 0.036) was observed. Univariate analysis showed association of 9q loss (p < 0.008) and 16q loss (p = 0.05) with adverse overall survival (OS). Chromosome 6 monosomy was a protective event although statistically borderline (p = 0.066). After adjusting for confounding factors, a poor OS was found for patients whose tumor has 9q loss [hazard ratio (HR) = 3.97; p < 0.006) or 16q loss (HR = 2.41; p = 0.038). Our results highlight the importance of genomic studies in different MB histological variants and indicate a genotype-phenotype correlation.
Lingua originaleEnglish
pagine (da-a)273-280
Numero di pagine8
RivistaOMICS
Volume15
DOI
Stato di pubblicazionePubblicato - 2011

Keywords

  • Chromosome 9q
  • aggressiveness
  • chromosome 16q
  • genome-wide pooled-analysis
  • medulloblastoma

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