CHEMICAL MODIFICATIONS OF SH-GROUPS OF INTRAERYTHROCYTIC HEMOGLOBIN

E Antonini; C Ioppolo; Bruno Giardina; M. Brunori

CHEMICAL MODIFICATIONS OF SH-GROUPS OF INTRAERYTHROCYTIC HEMOGLOBIN

E Antonini, C Ioppolo, Bruno Giardina, M. Brunori

Risultato della ricerca: Contributo in rivista › Articolo in rivista

Abstract

Chemical modifications of intraerythrocytic hemoglobin have been obtained by reaction of β 93 sulfhydryl groups with disulfides i.e. cystamine and cystine-dimethylester. The respiratory properties of the modified erythrocytes are similar to those of the hemoglobin reacted with the same reagents and the changes observed are the same for both compounds. Although other properties of the erythrocytes are modified, the resistance to hemolysis is not vastly impaired. The results suggest the possibility of using these compounds (or similar ones) to modify red cells for therapeutical purposes

Lingua originale	English
pagine (da-a)	1647-1655
Numero di pagine	9
Rivista	Biochemical and Biophysical Research Communications
Volume	74
Stato di pubblicazione	Pubblicato - 1977
Pubblicato esternamente	Sì

Keywords

INTRAERYTHROCYTIC HEMOGLOBIN

Altri file e collegamenti

Link a IRIS PubliCatt

Cita questo

@article{563a20ab764641f8a090b591f8079450,

title = "CHEMICAL MODIFICATIONS OF SH-GROUPS OF INTRAERYTHROCYTIC HEMOGLOBIN",

abstract = "Chemical modifications of intraerythrocytic hemoglobin have been obtained by reaction of β 93 sulfhydryl groups with disulfides i.e. cystamine and cystine-dimethylester. The respiratory properties of the modified erythrocytes are similar to those of the hemoglobin reacted with the same reagents and the changes observed are the same for both compounds. Although other properties of the erythrocytes are modified, the resistance to hemolysis is not vastly impaired. The results suggest the possibility of using these compounds (or similar ones) to modify red cells for therapeutical purposes",

keywords = "INTRAERYTHROCYTIC HEMOGLOBIN, INTRAERYTHROCYTIC HEMOGLOBIN",

author = "E Antonini and C Ioppolo and Bruno Giardina and M. Brunori",

year = "1977",

language = "English",

volume = "74",

pages = "1647--1655",

journal = "Biochemical and Biophysical Research Communications",

issn = "0006-291X",

publisher = "Academic Press Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)543-9534, (407)345-4100, EMAIL: [email protected], INTERNET: http://www.idealibrary.com, Fax: (407)352-3445",

}

TY - JOUR

T1 - CHEMICAL MODIFICATIONS OF SH-GROUPS OF INTRAERYTHROCYTIC HEMOGLOBIN

AU - Antonini, E

AU - Ioppolo, C

AU - Giardina, Bruno

AU - Brunori, M.

PY - 1977

Y1 - 1977

N2 - Chemical modifications of intraerythrocytic hemoglobin have been obtained by reaction of β 93 sulfhydryl groups with disulfides i.e. cystamine and cystine-dimethylester. The respiratory properties of the modified erythrocytes are similar to those of the hemoglobin reacted with the same reagents and the changes observed are the same for both compounds. Although other properties of the erythrocytes are modified, the resistance to hemolysis is not vastly impaired. The results suggest the possibility of using these compounds (or similar ones) to modify red cells for therapeutical purposes

AB - Chemical modifications of intraerythrocytic hemoglobin have been obtained by reaction of β 93 sulfhydryl groups with disulfides i.e. cystamine and cystine-dimethylester. The respiratory properties of the modified erythrocytes are similar to those of the hemoglobin reacted with the same reagents and the changes observed are the same for both compounds. Although other properties of the erythrocytes are modified, the resistance to hemolysis is not vastly impaired. The results suggest the possibility of using these compounds (or similar ones) to modify red cells for therapeutical purposes

KW - INTRAERYTHROCYTIC HEMOGLOBIN

UR - http://hdl.handle.net/10807/6835

M3 - Article

SN - 0006-291X

VL - 74

SP - 1647

EP - 1655

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

ER -

CHEMICAL MODIFICATIONS OF SH-GROUPS OF INTRAERYTHROCYTIC HEMOGLOBIN

Abstract

Keywords

Altri file e collegamenti

Fingerprint

Cita questo