Charlson comorbidity index and adult comorbidity evaluation-27 scores might predict treatment compliance and development of pleural effusions in elderly patients with chronic myeloid leukemia treated with second-line dasatinib

Simona Sica, Massimo Breccia, Roberto Latagliata, Fabio Stagno, Luigiana Luciano, Antonella Gozzini, Fausto Castagnetti, Carmen Fava, Francesco Cavazzini, Mario Annunziata, Antonella Russo Rossi, Patrizia Pregno, Elisabetta Abruzzese, Paolo Vigneri, Giovanna Rege-Cambrin, Fabrizio Pane, Valeria Santini, Giorgina Specchia, Gianantonio Rosti, Giuliana Alimena

Risultato della ricerca: Contributo in rivistaArticolo in rivista

47 Citazioni (Scopus)

Abstract

Comorbidities may affect survival and choice of treatment among cancer patients. In fact, comorbidities have been identified as significant determinants of response to therapy in older patients with acute myeloid leukemia, breast cancer, head and neck cancer, and lung cancer. The Charlson comorbidity index and adult comorbidity evaluation-27 are lists of comorbidities with a weight assigned from 1 to 6 for the former and from 0 to 3 for the latter score, derived from relative risk estimates of a proportional hazard regression model using clinical data.
Lingua originaleEnglish
pagine (da-a)1457-1461
Numero di pagine5
RivistaHaematologica
Volume96
DOI
Stato di pubblicazionePubblicato - 2011

Keywords

  • Aged
  • Antineoplastic Agents
  • Female
  • Humans
  • Incidence
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive
  • Male
  • Medication Adherence
  • Pleural Effusion
  • Protein Kinase Inhibitors
  • Pyrimidines
  • Retrospective Studies
  • Thiazoles
  • Treatment Outcome

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