Characterization of the human salivary basic proline-rich protein complex by a proteomic approach

Irene Messana, Tiziana Cabras, Rosanna Inzitari, Alessandro Lupi, Cecilia Zuppi, Chiara Olmi, Maria Benedetta Fadda, Massimo Cordaro, Bruno Giardina, Massimo Castagnola

Risultato della ricerca: Contributo in rivistaArticolo in rivista

88 Citazioni (Scopus)


Thirteen samples of human normal whole saliva were analyzed by RP-HPLC-ESI-MS and MALDI-TOF-MS to investigate the basic proline-rich protein complex. Between known basic-PRPs the P-B, P-C (or IB-8b), P-D (or IB-5), P-E (or IB-9), P-F (or IB-8), P-H (or IB-4), IB-6,II-2, IB-1, and IB-8a glucosylated were identified, whereas the II-1, IB-7, PA, and D1-A peptides were not detected. Some detected masses not attributable to known basic-PRPs were putatively ascribed to II-2 and IB-1 nonphosphorylated, II-2 and IB-1 missing the C-terminal arginine residue, and the 1-62 fragment of IB-6, named P-J peptide. A correlation matrix analysis revealed a cluster of correlation among all the basic PRF's (apart from the P-B peptide) which is in agreement with their common parotid origin.
Lingua originaleEnglish
pagine (da-a)792-800
Numero di pagine9
RivistaJournal of Proteome Research
Stato di pubblicazionePubblicato - 2004




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