Characteristics and patterns of care of endometrial cancer before and during COVID-19 pandemic

Giovanni Scambia; Francesco Fanfani; Maria Gabriella Ferrandina; Barbara Costantini; Matteo Loverro; Antonio Agostino Pellegrino; Stefano Montoli; Gianluca Comerci; Pierfrancesco Greco; Marco Morelli; Stefano Cianci; Alfredo Ercoli; Sergio Schettini; Marcello Ceccaroni; Silvia Amodeo; Maria Laura Leo; Antonio Dell'Acqua; Marco Petrillo; Federica Romano; Giuseppe Ricci; Giorgio Bogani; Chiara Cimmino; Fabio Landoni; Luca Bazzurini; Tommaso Grassi; Domenico Vitobello; Gabriele Siesto; Anna Myriam Perrone; Vanna Zanagnolo; Pierandrea De Iaco; Francesco Multinu; Fabio Ghezzi; Jvan Casarin; Roberto Berretta; Errico Zupi; Gabriele Centini; Antonio Pellegrino; Silvia Corso; Guido Stevenazzi; Serena Montoli; Anna Chiara Boschi; Giuseppe Comerci; Pantaleo Greco; Ruby Martinello; Francesco Sopracordevole; Giorgio Giorda; Tommaso Simoncini; Marta Caretto; Enrico Sartori; Federico Ferrari; Antonio Cianci; Giuseppe Sarpietro; Maria Grazia Matarazzo; Fulvio Zullo; Giuseppe Bifulco; Michele Morelli; Annamaria Ferrero; Nicoletta Biglia; Fabio Barra; Simone Ferrero; Umberto Leone Roberti Maggiore; Giulio Sozzi; Angela Martoccia; Teresa Orlando; Francesco G. Cannone; Giuseppe Ettore; Andrea Puppo; Martina Borghese; Canio Martinelli; Violante Di Donato; Lorenza Driul; Alice Bergamini; Giorgio Candotti; Luca Bocciolone; Francesco Plotti; Roberto Angioli; Giulia Mantovani; Chiara Cassani; Mattia Dominoni; Laura Giambanco; Livio Leo; Raphael Thomasset; Diego Raimondo; Renato Seracchioli; Mario Malzoni; Franco Gorlero; Martina Di Luca; Enrico Busato; Sami Kilzie; Andrea Dell'Acqua; Giovanna Scarfone; Paolo Vercellini; Salvatore Dessole; Giampiero Capobianco; Andrea Ciavattini; Giovanni Delli Carpini; Luca Giannella; Liliana Mereu; Saverio Tateo; Flavia Sorbi; Massimiliano Fambrini; Stefania Cicogna; Federico Romano; Giuseppe Trojano; Roberto Consonni; Simona Cantaluppi; Antonio Lippolis; Raffaele Tinelli; Giovanni D'Ippolito; Lorenzo Aguzzoli; Vincenzo D. Mandato; Stefano Palomba; Davide Calandra; Maurizio Rosati; Cinzia Gallo; Daniela Surico; Valentino Remorgida; Francesco Ruscitto; Paolo Beretta; Pierluigi Benedetti Panici; Francesco Raspagliesi

doi:10.3802/JGO.2022.33.E10

Characteristics and patterns of care of endometrial cancer before and during COVID-19 pandemic

Giovanni Scambia, Francesco Fanfani, Maria Gabriella Ferrandina, Barbara Costantini, Matteo Loverro, Antonio Agostino Pellegrino, Stefano Montoli, Gianluca Comerci, Pierfrancesco Greco, Marco Morelli, Stefano Cianci, Alfredo Ercoli, Sergio Schettini, Marcello Ceccaroni, Silvia Amodeo, Maria Laura Leo, Antonio Dell'Acqua, Marco Petrillo, Federica Romano, Giuseppe RicciGiorgio Bogani, Chiara Cimmino, Fabio Landoni, Luca Bazzurini, Tommaso Grassi, Domenico Vitobello, Gabriele Siesto, Anna Myriam Perrone, Vanna Zanagnolo, Pierandrea De Iaco, Francesco Multinu, Fabio Ghezzi, Jvan Casarin, Roberto Berretta, Errico Zupi, Gabriele Centini, Antonio Pellegrino, Silvia Corso, Guido Stevenazzi, Serena Montoli, Anna Chiara Boschi, Giuseppe Comerci, Pantaleo Greco, Ruby Martinello, Francesco Sopracordevole, Giorgio Giorda, Tommaso Simoncini, Marta Caretto, Enrico Sartori, Federico Ferrari, Antonio Cianci, Giuseppe Sarpietro, Maria Grazia Matarazzo, Fulvio Zullo, Giuseppe Bifulco, Michele Morelli, Annamaria Ferrero, Nicoletta Biglia, Fabio Barra, Simone Ferrero, Umberto Leone Roberti Maggiore, Giulio Sozzi, Angela Martoccia, Teresa Orlando, Francesco G. Cannone, Giuseppe Ettore, Andrea Puppo, Martina Borghese, Canio Martinelli, Violante Di Donato, Lorenza Driul, Alice Bergamini, Giorgio Candotti, Luca Bocciolone, Francesco Plotti, Roberto Angioli, Giulia Mantovani, Chiara Cassani, Mattia Dominoni, Laura Giambanco, Livio Leo, Raphael Thomasset, Diego Raimondo, Renato Seracchioli, Mario Malzoni, Franco Gorlero, Martina Di Luca, Enrico Busato, Sami Kilzie, Andrea Dell'Acqua, Giovanna Scarfone, Paolo Vercellini, Salvatore Dessole, Giampiero Capobianco, Andrea Ciavattini, Giovanni Delli Carpini, Luca Giannella, Liliana Mereu, Saverio Tateo, Flavia Sorbi, Massimiliano Fambrini, Stefania Cicogna, Federico Romano, Giuseppe Trojano, Roberto Consonni, Simona Cantaluppi, Antonio Lippolis, Raffaele Tinelli, Giovanni D'Ippolito, Lorenzo Aguzzoli, Vincenzo D. Mandato, Stefano Palomba, Davide Calandra, Maurizio Rosati, Cinzia Gallo, Daniela Surico, Valentino Remorgida, Francesco Ruscitto, Paolo Beretta, Pierluigi Benedetti Panici, Francesco Raspagliesi

Risultato della ricerca: Contributo in rivista › Articolo in rivista

Abstract

Objective: Coronavirus disease 2019 (COVID-19) outbreak has correlated with the disruption of screening activities and diagnostic assessments. Endometrial cancer (EC) is one of the most common gynecological malignancies and it is often detected at an early stage, because it frequently produces symptoms. Here, we aim to investigate the impact of COVID-19 outbreak on patterns of presentation and treatment of EC patients. Methods: This is a retrospective study involving 54 centers in Italy. We evaluated patterns of presentation and treatment of EC patients before (period 1: March 1, 2019 to February 29, 2020) and during (period 2: April 1, 2020 to March 31, 2021) the COVID-19 outbreak. Results: Medical records of 5,164 EC patients have been retrieved: 2,718 and 2,446 women treated in period 1 and period 2, respectively. Surgery was the mainstay of treatment in both periods (p=0.356). Nodal assessment was omitted in 689 (27.3%) and 484 (21.2%) patients treated in period 1 and 2, respectively (p<0.001). While, the prevalence of patients undergoing sentinel node mapping (with or without backup lymphadenectomy) has increased during the COVID-19 pandemic (46.7% in period 1 vs. 52.8% in period 2; p<0.001). Overall, 1,280 (50.4%) and 1,021 (44.7%) patients had no adjuvant therapy in period 1 and 2, respectively (p<0.001). Adjuvant therapy use has increased during COVID-19 pandemic (p<0.001). Conclusion: Our data suggest that the COVID-19 pandemic had a significant impact on the characteristics and patterns of care of EC patients. These findings highlight the need to implement healthcare services during the pandemic.

Lingua originale	English
pagine (da-a)	50-56
Numero di pagine	7
Rivista	Journal of Gynecologic Oncology
Volume	33
DOI	https://doi.org/10.3802/JGO.2022.33.E10
Stato di pubblicazione	Pubblicato - 2022

Keywords

COVID-19
Endometrial Cancer
SARS-CoV-2
Uterine cancer
Female
Endometrial Neoplasms
Pandemics
Retrospective Studies
Humans

Accesso al documento

10.3802/JGO.2022.33.E10

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Scambia, G., Fanfani, F., Ferrandina, M. G., Costantini, B., Loverro, M., Pellegrino, A. A., Montoli, S., Comerci, G., Greco, P., Morelli, M., Cianci, S., Ercoli, A., Schettini, S., Ceccaroni, M., Amodeo, S., Leo, M. L., Dell'Acqua, A., Petrillo, M., Romano, F., ... Raspagliesi, F. (2022). Characteristics and patterns of care of endometrial cancer before and during COVID-19 pandemic. Journal of Gynecologic Oncology, 33, 50-56. https://doi.org/10.3802/JGO.2022.33.E10

Scambia, Giovanni ; Fanfani, Francesco ; Ferrandina, Maria Gabriella ; Costantini, Barbara ; Loverro, Matteo ; Pellegrino, Antonio Agostino ; Montoli, Stefano ; Comerci, Gianluca ; Greco, Pierfrancesco ; Morelli, Marco ; Cianci, Stefano ; Ercoli, Alfredo ; Schettini, Sergio ; Ceccaroni, Marcello ; Amodeo, Silvia ; Leo, Maria Laura ; Dell'Acqua, Antonio ; Petrillo, Marco ; Romano, Federica ; Ricci, Giuseppe ; Bogani, Giorgio ; Cimmino, Chiara ; Landoni, Fabio ; Bazzurini, Luca ; Grassi, Tommaso ; Vitobello, Domenico ; Siesto, Gabriele ; Perrone, Anna Myriam ; Zanagnolo, Vanna ; De Iaco, Pierandrea ; Multinu, Francesco ; Ghezzi, Fabio ; Casarin, Jvan ; Berretta, Roberto ; Zupi, Errico ; Centini, Gabriele ; Pellegrino, Antonio ; Corso, Silvia ; Stevenazzi, Guido ; Montoli, Serena ; Boschi, Anna Chiara ; Comerci, Giuseppe ; Greco, Pantaleo ; Martinello, Ruby ; Sopracordevole, Francesco ; Giorda, Giorgio ; Simoncini, Tommaso ; Caretto, Marta ; Sartori, Enrico ; Ferrari, Federico ; Cianci, Antonio ; Sarpietro, Giuseppe ; Matarazzo, Maria Grazia ; Zullo, Fulvio ; Bifulco, Giuseppe ; Morelli, Michele ; Ferrero, Annamaria ; Biglia, Nicoletta ; Barra, Fabio ; Ferrero, Simone ; Maggiore, Umberto Leone Roberti ; Sozzi, Giulio ; Martoccia, Angela ; Orlando, Teresa ; Cannone, Francesco G. ; Ettore, Giuseppe ; Puppo, Andrea ; Borghese, Martina ; Martinelli, Canio ; Di Donato, Violante ; Driul, Lorenza ; Bergamini, Alice ; Candotti, Giorgio ; Bocciolone, Luca ; Plotti, Francesco ; Angioli, Roberto ; Mantovani, Giulia ; Cassani, Chiara ; Dominoni, Mattia ; Giambanco, Laura ; Leo, Livio ; Thomasset, Raphael ; Raimondo, Diego ; Seracchioli, Renato ; Malzoni, Mario ; Gorlero, Franco ; Di Luca, Martina ; Busato, Enrico ; Kilzie, Sami ; Dell'Acqua, Andrea ; Scarfone, Giovanna ; Vercellini, Paolo ; Dessole, Salvatore ; Capobianco, Giampiero ; Ciavattini, Andrea ; Delli Carpini, Giovanni ; Giannella, Luca ; Mereu, Liliana ; Tateo, Saverio ; Sorbi, Flavia ; Fambrini, Massimiliano ; Cicogna, Stefania ; Romano, Federico ; Trojano, Giuseppe ; Consonni, Roberto ; Cantaluppi, Simona ; Lippolis, Antonio ; Tinelli, Raffaele ; D'Ippolito, Giovanni ; Aguzzoli, Lorenzo ; Mandato, Vincenzo D. ; Palomba, Stefano ; Calandra, Davide ; Rosati, Maurizio ; Gallo, Cinzia ; Surico, Daniela ; Remorgida, Valentino ; Ruscitto, Francesco ; Beretta, Paolo ; Panici, Pierluigi Benedetti ; Raspagliesi, Francesco. / Characteristics and patterns of care of endometrial cancer before and during COVID-19 pandemic. In: Journal of Gynecologic Oncology. 2022 ; Vol. 33. pagg. 50-56.

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title = "Characteristics and patterns of care of endometrial cancer before and during COVID-19 pandemic",

abstract = "Objective: Coronavirus disease 2019 (COVID-19) outbreak has correlated with the disruption of screening activities and diagnostic assessments. Endometrial cancer (EC) is one of the most common gynecological malignancies and it is often detected at an early stage, because it frequently produces symptoms. Here, we aim to investigate the impact of COVID-19 outbreak on patterns of presentation and treatment of EC patients. Methods: This is a retrospective study involving 54 centers in Italy. We evaluated patterns of presentation and treatment of EC patients before (period 1: March 1, 2019 to February 29, 2020) and during (period 2: April 1, 2020 to March 31, 2021) the COVID-19 outbreak. Results: Medical records of 5,164 EC patients have been retrieved: 2,718 and 2,446 women treated in period 1 and period 2, respectively. Surgery was the mainstay of treatment in both periods (p=0.356). Nodal assessment was omitted in 689 (27.3%) and 484 (21.2%) patients treated in period 1 and 2, respectively (p<0.001). While, the prevalence of patients undergoing sentinel node mapping (with or without backup lymphadenectomy) has increased during the COVID-19 pandemic (46.7% in period 1 vs. 52.8% in period 2; p<0.001). Overall, 1,280 (50.4%) and 1,021 (44.7%) patients had no adjuvant therapy in period 1 and 2, respectively (p<0.001). Adjuvant therapy use has increased during COVID-19 pandemic (p<0.001). Conclusion: Our data suggest that the COVID-19 pandemic had a significant impact on the characteristics and patterns of care of EC patients. These findings highlight the need to implement healthcare services during the pandemic.",

keywords = "COVID-19, Endometrial Cancer, SARS-CoV-2, Uterine cancer, Female, Endometrial Neoplasms, Pandemics, Retrospective Studies, Humans, COVID-19, Endometrial Cancer, SARS-CoV-2, Uterine cancer, Female, Endometrial Neoplasms, Pandemics, Retrospective Studies, Humans",

author = "Giovanni Scambia and Francesco Fanfani and Ferrandina, {Maria Gabriella} and Barbara Costantini and Matteo Loverro and Pellegrino, {Antonio Agostino} and Stefano Montoli and Gianluca Comerci and Pierfrancesco Greco and Marco Morelli and Stefano Cianci and Alfredo Ercoli and Sergio Schettini and Marcello Ceccaroni and Silvia Amodeo and Leo, {Maria Laura} and Antonio Dell'Acqua and Marco Petrillo and Federica Romano and Giuseppe Ricci and Giorgio Bogani and Chiara Cimmino and Fabio Landoni and Luca Bazzurini and Tommaso Grassi and Domenico Vitobello and Gabriele Siesto and Perrone, {Anna Myriam} and Vanna Zanagnolo and {De Iaco}, Pierandrea and Francesco Multinu and Fabio Ghezzi and Jvan Casarin and Roberto Berretta and Errico Zupi and Gabriele Centini and Antonio Pellegrino and Silvia Corso and Guido Stevenazzi and Serena Montoli and Boschi, {Anna Chiara} and Giuseppe Comerci and Pantaleo Greco and Ruby Martinello and Francesco Sopracordevole and Giorgio Giorda and Tommaso Simoncini and Marta Caretto and Enrico Sartori and Federico Ferrari and Antonio Cianci and Giuseppe Sarpietro and Matarazzo, {Maria Grazia} and Fulvio Zullo and Giuseppe Bifulco and Michele Morelli and Annamaria Ferrero and Nicoletta Biglia and Fabio Barra and Simone Ferrero and Maggiore, {Umberto Leone Roberti} and Giulio Sozzi and Angela Martoccia and Teresa Orlando and Cannone, {Francesco G.} and Giuseppe Ettore and Andrea Puppo and Martina Borghese and Canio Martinelli and {Di Donato}, Violante and Lorenza Driul and Alice Bergamini and Giorgio Candotti and Luca Bocciolone and Francesco Plotti and Roberto Angioli and Giulia Mantovani and Chiara Cassani and Mattia Dominoni and Laura Giambanco and Livio Leo and Raphael Thomasset and Diego Raimondo and Renato Seracchioli and Mario Malzoni and Franco Gorlero and {Di Luca}, Martina and Enrico Busato and Sami Kilzie and Andrea Dell'Acqua and Giovanna Scarfone and Paolo Vercellini and Salvatore Dessole and Giampiero Capobianco and Andrea Ciavattini and {Delli Carpini}, Giovanni and Luca Giannella and Liliana Mereu and Saverio Tateo and Flavia Sorbi and Massimiliano Fambrini and Stefania Cicogna and Federico Romano and Giuseppe Trojano and Roberto Consonni and Simona Cantaluppi and Antonio Lippolis and Raffaele Tinelli and Giovanni D'Ippolito and Lorenzo Aguzzoli and Mandato, {Vincenzo D.} and Stefano Palomba and Davide Calandra and Maurizio Rosati and Cinzia Gallo and Daniela Surico and Valentino Remorgida and Francesco Ruscitto and Paolo Beretta and Panici, {Pierluigi Benedetti} and Francesco Raspagliesi",

year = "2022",

doi = "10.3802/JGO.2022.33.E10",

language = "English",

volume = "33",

pages = "50--56",

journal = "Journal of Gynecologic Oncology",

issn = "2005-0380",

publisher = "-Seoul: Asian Society of Gynecologic Oncology ; Korean Society of Gynecologic Oncology and Colposcopy, 2011 -Seoul : Korean society of gynecologic oncology and colposcopy",

}

Scambia, G , Fanfani, F , Ferrandina, MG, Costantini, B, Loverro, M, Pellegrino, AA, Montoli, S, Comerci, G, Greco, P, Morelli, M, Cianci, S, Ercoli, A, Schettini, S, Ceccaroni, M, Amodeo, S, Leo, ML, Dell'Acqua, A, Petrillo, M, Romano, F, Ricci, G, Bogani, G, Cimmino, C, Landoni, F, Bazzurini, L, Grassi, T, Vitobello, D, Siesto, G, Perrone, AM, Zanagnolo, V, De Iaco, P, Multinu, F, Ghezzi, F, Casarin, J, Berretta, R, Zupi, E, Centini, G, Pellegrino, A, Corso, S, Stevenazzi, G, Montoli, S, Boschi, AC, Comerci, G, Greco, P, Martinello, R, Sopracordevole, F, Giorda, G, Simoncini, T, Caretto, M, Sartori, E, Ferrari, F, Cianci, A, Sarpietro, G, Matarazzo, MG, Zullo, F, Bifulco, G, Morelli, M, Ferrero, A, Biglia, N, Barra, F, Ferrero, S, Maggiore, ULR, Sozzi, G, Martoccia, A, Orlando, T, Cannone, FG, Ettore, G, Puppo, A, Borghese, M, Martinelli, C, Di Donato, V, Driul, L, Bergamini, A, Candotti, G, Bocciolone, L, Plotti, F, Angioli, R, Mantovani, G, Cassani, C, Dominoni, M, Giambanco, L, Leo, L, Thomasset, R, Raimondo, D, Seracchioli, R, Malzoni, M, Gorlero, F, Di Luca, M, Busato, E, Kilzie, S, Dell'Acqua, A, Scarfone, G, Vercellini, P, Dessole, S, Capobianco, G, Ciavattini, A, Delli Carpini, G, Giannella, L, Mereu, L, Tateo, S, Sorbi, F, Fambrini, M, Cicogna, S, Romano, F, Trojano, G, Consonni, R, Cantaluppi, S, Lippolis, A, Tinelli, R, D'Ippolito, G, Aguzzoli, L, Mandato, VD, Palomba, S, Calandra, D, Rosati, M, Gallo, C, Surico, D, Remorgida, V, Ruscitto, F, Beretta, P, Panici, PB & Raspagliesi, F 2022, 'Characteristics and patterns of care of endometrial cancer before and during COVID-19 pandemic', Journal of Gynecologic Oncology, vol. 33, pagg. 50-56. https://doi.org/10.3802/JGO.2022.33.E10

Characteristics and patterns of care of endometrial cancer before and during COVID-19 pandemic. / Scambia, Giovanni ; Fanfani, Francesco ; Ferrandina, Maria Gabriella; Costantini, Barbara; Loverro, Matteo; Pellegrino, Antonio Agostino; Montoli, Stefano; Comerci, Gianluca; Greco, Pierfrancesco; Morelli, Marco; Cianci, Stefano; Ercoli, Alfredo; Schettini, Sergio; Ceccaroni, Marcello; Amodeo, Silvia; Leo, Maria Laura; Dell'Acqua, Antonio; Petrillo, Marco; Romano, Federica; Ricci, Giuseppe; Bogani, Giorgio; Cimmino, Chiara; Landoni, Fabio; Bazzurini, Luca; Grassi, Tommaso; Vitobello, Domenico; Siesto, Gabriele; Perrone, Anna Myriam; Zanagnolo, Vanna; De Iaco, Pierandrea; Multinu, Francesco; Ghezzi, Fabio; Casarin, Jvan; Berretta, Roberto; Zupi, Errico; Centini, Gabriele; Pellegrino, Antonio; Corso, Silvia; Stevenazzi, Guido; Montoli, Serena; Boschi, Anna Chiara; Comerci, Giuseppe; Greco, Pantaleo; Martinello, Ruby; Sopracordevole, Francesco; Giorda, Giorgio; Simoncini, Tommaso; Caretto, Marta; Sartori, Enrico; Ferrari, Federico; Cianci, Antonio; Sarpietro, Giuseppe; Matarazzo, Maria Grazia; Zullo, Fulvio; Bifulco, Giuseppe; Morelli, Michele; Ferrero, Annamaria; Biglia, Nicoletta; Barra, Fabio; Ferrero, Simone; Maggiore, Umberto Leone Roberti; Sozzi, Giulio; Martoccia, Angela; Orlando, Teresa; Cannone, Francesco G.; Ettore, Giuseppe; Puppo, Andrea; Borghese, Martina; Martinelli, Canio; Di Donato, Violante; Driul, Lorenza; Bergamini, Alice; Candotti, Giorgio; Bocciolone, Luca; Plotti, Francesco; Angioli, Roberto; Mantovani, Giulia; Cassani, Chiara; Dominoni, Mattia; Giambanco, Laura; Leo, Livio; Thomasset, Raphael; Raimondo, Diego; Seracchioli, Renato; Malzoni, Mario; Gorlero, Franco; Di Luca, Martina; Busato, Enrico; Kilzie, Sami; Dell'Acqua, Andrea; Scarfone, Giovanna; Vercellini, Paolo; Dessole, Salvatore; Capobianco, Giampiero; Ciavattini, Andrea; Delli Carpini, Giovanni; Giannella, Luca; Mereu, Liliana; Tateo, Saverio; Sorbi, Flavia; Fambrini, Massimiliano; Cicogna, Stefania; Romano, Federico; Trojano, Giuseppe; Consonni, Roberto; Cantaluppi, Simona; Lippolis, Antonio; Tinelli, Raffaele; D'Ippolito, Giovanni; Aguzzoli, Lorenzo; Mandato, Vincenzo D.; Palomba, Stefano; Calandra, Davide; Rosati, Maurizio; Gallo, Cinzia; Surico, Daniela; Remorgida, Valentino; Ruscitto, Francesco; Beretta, Paolo; Panici, Pierluigi Benedetti; Raspagliesi, Francesco.

In: Journal of Gynecologic Oncology, Vol. 33, 2022, pag. 50-56.

Risultato della ricerca: Contributo in rivista › Articolo in rivista

TY - JOUR

T1 - Characteristics and patterns of care of endometrial cancer before and during COVID-19 pandemic

AU - Scambia, Giovanni

AU - Fanfani, Francesco

AU - Ferrandina, Maria Gabriella

AU - Costantini, Barbara

AU - Loverro, Matteo

AU - Pellegrino, Antonio Agostino

AU - Montoli, Stefano

AU - Comerci, Gianluca

AU - Greco, Pierfrancesco

AU - Morelli, Marco

AU - Cianci, Stefano

AU - Ercoli, Alfredo

AU - Schettini, Sergio

AU - Ceccaroni, Marcello

AU - Amodeo, Silvia

AU - Leo, Maria Laura

AU - Dell'Acqua, Antonio

AU - Petrillo, Marco

AU - Romano, Federica

AU - Ricci, Giuseppe

AU - Bogani, Giorgio

AU - Cimmino, Chiara

AU - Landoni, Fabio

AU - Bazzurini, Luca

AU - Grassi, Tommaso

AU - Vitobello, Domenico

AU - Siesto, Gabriele

AU - Perrone, Anna Myriam

AU - Zanagnolo, Vanna

AU - De Iaco, Pierandrea

AU - Multinu, Francesco

AU - Ghezzi, Fabio

AU - Casarin, Jvan

AU - Berretta, Roberto

AU - Zupi, Errico

AU - Centini, Gabriele

AU - Pellegrino, Antonio

AU - Corso, Silvia

AU - Stevenazzi, Guido

AU - Montoli, Serena

AU - Boschi, Anna Chiara

AU - Comerci, Giuseppe

AU - Greco, Pantaleo

AU - Martinello, Ruby

AU - Sopracordevole, Francesco

AU - Giorda, Giorgio

AU - Simoncini, Tommaso

AU - Caretto, Marta

AU - Sartori, Enrico

AU - Ferrari, Federico

AU - Cianci, Antonio

AU - Sarpietro, Giuseppe

AU - Matarazzo, Maria Grazia

AU - Zullo, Fulvio

AU - Bifulco, Giuseppe

AU - Morelli, Michele

AU - Ferrero, Annamaria

AU - Biglia, Nicoletta

AU - Barra, Fabio

AU - Ferrero, Simone

AU - Maggiore, Umberto Leone Roberti

AU - Sozzi, Giulio

AU - Martoccia, Angela

AU - Orlando, Teresa

AU - Cannone, Francesco G.

AU - Ettore, Giuseppe

AU - Puppo, Andrea

AU - Borghese, Martina

AU - Martinelli, Canio

AU - Di Donato, Violante

AU - Driul, Lorenza

AU - Bergamini, Alice

AU - Candotti, Giorgio

AU - Bocciolone, Luca

AU - Plotti, Francesco

AU - Angioli, Roberto

AU - Mantovani, Giulia

AU - Cassani, Chiara

AU - Dominoni, Mattia

AU - Giambanco, Laura

AU - Leo, Livio

AU - Thomasset, Raphael

AU - Raimondo, Diego

AU - Seracchioli, Renato

AU - Malzoni, Mario

AU - Gorlero, Franco

AU - Di Luca, Martina

AU - Busato, Enrico

AU - Kilzie, Sami

AU - Dell'Acqua, Andrea

AU - Scarfone, Giovanna

AU - Vercellini, Paolo

AU - Dessole, Salvatore

AU - Capobianco, Giampiero

AU - Ciavattini, Andrea

AU - Delli Carpini, Giovanni

AU - Giannella, Luca

AU - Mereu, Liliana

AU - Tateo, Saverio

AU - Sorbi, Flavia

AU - Fambrini, Massimiliano

AU - Cicogna, Stefania

AU - Romano, Federico

AU - Trojano, Giuseppe

AU - Consonni, Roberto

AU - Cantaluppi, Simona

AU - Lippolis, Antonio

AU - Tinelli, Raffaele

AU - D'Ippolito, Giovanni

AU - Aguzzoli, Lorenzo

AU - Mandato, Vincenzo D.

AU - Palomba, Stefano

AU - Calandra, Davide

AU - Rosati, Maurizio

AU - Gallo, Cinzia

AU - Surico, Daniela

AU - Remorgida, Valentino

AU - Ruscitto, Francesco

AU - Beretta, Paolo

AU - Panici, Pierluigi Benedetti

AU - Raspagliesi, Francesco

PY - 2022

Y1 - 2022

N2 - Objective: Coronavirus disease 2019 (COVID-19) outbreak has correlated with the disruption of screening activities and diagnostic assessments. Endometrial cancer (EC) is one of the most common gynecological malignancies and it is often detected at an early stage, because it frequently produces symptoms. Here, we aim to investigate the impact of COVID-19 outbreak on patterns of presentation and treatment of EC patients. Methods: This is a retrospective study involving 54 centers in Italy. We evaluated patterns of presentation and treatment of EC patients before (period 1: March 1, 2019 to February 29, 2020) and during (period 2: April 1, 2020 to March 31, 2021) the COVID-19 outbreak. Results: Medical records of 5,164 EC patients have been retrieved: 2,718 and 2,446 women treated in period 1 and period 2, respectively. Surgery was the mainstay of treatment in both periods (p=0.356). Nodal assessment was omitted in 689 (27.3%) and 484 (21.2%) patients treated in period 1 and 2, respectively (p<0.001). While, the prevalence of patients undergoing sentinel node mapping (with or without backup lymphadenectomy) has increased during the COVID-19 pandemic (46.7% in period 1 vs. 52.8% in period 2; p<0.001). Overall, 1,280 (50.4%) and 1,021 (44.7%) patients had no adjuvant therapy in period 1 and 2, respectively (p<0.001). Adjuvant therapy use has increased during COVID-19 pandemic (p<0.001). Conclusion: Our data suggest that the COVID-19 pandemic had a significant impact on the characteristics and patterns of care of EC patients. These findings highlight the need to implement healthcare services during the pandemic.

AB - Objective: Coronavirus disease 2019 (COVID-19) outbreak has correlated with the disruption of screening activities and diagnostic assessments. Endometrial cancer (EC) is one of the most common gynecological malignancies and it is often detected at an early stage, because it frequently produces symptoms. Here, we aim to investigate the impact of COVID-19 outbreak on patterns of presentation and treatment of EC patients. Methods: This is a retrospective study involving 54 centers in Italy. We evaluated patterns of presentation and treatment of EC patients before (period 1: March 1, 2019 to February 29, 2020) and during (period 2: April 1, 2020 to March 31, 2021) the COVID-19 outbreak. Results: Medical records of 5,164 EC patients have been retrieved: 2,718 and 2,446 women treated in period 1 and period 2, respectively. Surgery was the mainstay of treatment in both periods (p=0.356). Nodal assessment was omitted in 689 (27.3%) and 484 (21.2%) patients treated in period 1 and 2, respectively (p<0.001). While, the prevalence of patients undergoing sentinel node mapping (with or without backup lymphadenectomy) has increased during the COVID-19 pandemic (46.7% in period 1 vs. 52.8% in period 2; p<0.001). Overall, 1,280 (50.4%) and 1,021 (44.7%) patients had no adjuvant therapy in period 1 and 2, respectively (p<0.001). Adjuvant therapy use has increased during COVID-19 pandemic (p<0.001). Conclusion: Our data suggest that the COVID-19 pandemic had a significant impact on the characteristics and patterns of care of EC patients. These findings highlight the need to implement healthcare services during the pandemic.

KW - COVID-19

KW - Endometrial Cancer

KW - SARS-CoV-2

KW - Uterine cancer

KW - Female

KW - Endometrial Neoplasms

KW - Pandemics

KW - Retrospective Studies

KW - Humans

KW - COVID-19

KW - Endometrial Cancer

KW - SARS-CoV-2

KW - Uterine cancer

KW - Female

KW - Endometrial Neoplasms

KW - Pandemics

KW - Retrospective Studies

KW - Humans

UR - http://hdl.handle.net/10807/198485

U2 - 10.3802/JGO.2022.33.E10

DO - 10.3802/JGO.2022.33.E10

M3 - Article

VL - 33

SP - 50

EP - 56

JO - Journal of Gynecologic Oncology

JF - Journal of Gynecologic Oncology

SN - 2005-0380

ER -

Characteristics and patterns of care of endometrial cancer before and during COVID-19 pandemic

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