[Changes in liver protein synthesis in the preterm newborn infant of a pre-eclamptic mother and/or with intrauterine growth retardation]

Antonio Alberto Zuppa, Giuseppe Gio Batta Tortorolo, G Maragliano, Martina Mazzotta, P Girlando, G Marrocco

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

To verify in the preterm newborn the hypothesis, recently proposed by some authors, of an hepatosynthetic deficiency, blood fibrinogen (FIB), prothrombin time (PT) and albumin (ALB) levels at birth were studied in 44 neonates, selected to obtain 4 groups of the same number and gestational age, different only for the presence of intrauterine growth retard and preeclampsia during pregnancy. In the newborns born of preeclamptic pregnancies, FIB, PT and ALB blood levels at birth resulted lower, but not significantly, than in those born of normal pregnancies; in SGA newborns the values (except for albumin) resulted significantly lower than in AGA newborns (FIB = 168 +/- 63 mg/dl vs 223 +/- 55 mg/dl; p < 0.01; PT = 51 +/- 15% vs 71 +/- 19%; p < 0.001). Besides, PT values resulted significantly lower (p < 0.01), in presence of normal pregnancy, in SGA than in AGA newborns, while FIB values resulted significantly lower (p < 0.01), in presence of preeclampsia, in SGA than in AGA newborns. It seems that, in preterm newborn, the intrauterine growth retard, rather than preeclampsia, would condition lower blood levels of the examined seric proteins. These results could be explained by hypothesizing, in the SGA preterm newborn, 3 possible etiopathogenetic mechanisms: 1) increased turnover of hepatosynthetized seric proteins, such as albumin; 2) deficiency of liver enzymes involved in proteic synthesis, already demonstrated for some coagulation factors; 3) diminished amino acidic substratum, necessary for proteic hepatosynthesis, caused by poor amino acidic passage through placenta, possible in presence of intrauterine growth retard. This would probably be the most important mechanism in causing low levels of the examined seric proteins.
Titolo tradotto del contributo[Autom. eng. transl.] [Changes in liver protein synthesis in the preterm newborn infant of a pre-eclamptic mother and/or with intrauterine growth retardation]
Lingua originaleItalian
pagine (da-a)359-362
Numero di pagine4
RivistaPediatria Medica e Chirurgica
Volume16
Stato di pubblicazionePubblicato - 1994

Keywords

  • Adult
  • Female
  • Fetal Growth Retardation
  • Fibrinogen
  • Humans
  • Infant, Newborn
  • Infant, Premature
  • Infant, Small for Gestational Age
  • Liver
  • Pre-Eclampsia
  • Pregnancy
  • Protein Biosynthesis
  • Prothrombin
  • Serum Albumin

Fingerprint

Entra nei temi di ricerca di '[Changes in liver protein synthesis in the preterm newborn infant of a pre-eclamptic mother and/or with intrauterine growth retardation]'. Insieme formano una fingerprint unica.

Cita questo