Changes in insulin sensitivity and secretion after sleeve gastrectomy

G. Casella, E. Soricelli, L. Castagneto-Gissey, A. Redler, N. Basso, Geltrude Mingrone

Risultato della ricerca: Contributo in rivistaArticolo in rivista

17 Citazioni (SciVal)


Background Sleeve gastrectomy is indicated for the treatment of obesity and related co-morbidity including diabetes. The dynamic changes in insulin secretion and sensitivity after sleeve gastrectomy are unknown. Methods Whole-body insulin sensitivity was measured by the euglycaemic hyperinsulinaemic clamp technique, and insulin secretion by C-peptide deconvolution after an oral glucose tolerance test (OGTT), before and 3, 6 and 12 months after sleeve gastrectomy in morbidly obese subjects. The time course of glucagon-like peptide (GLP) 1, as a marker of insulin secretion following OGTT, was also assessed. Results Ten patients were included in the study. Median (range) baseline insulin sensitivity (M-value) increased from 84·0 (20·2-131·4) mmol per kg per min at baseline to 122·8 (99·0-179·3) mmol per kg per min at 12 months after surgery (P = 0·015). Fasting insulin sensitivity, measured by homeostatic model assessment of insulin resistance, which represents a surrogate index of hepatic insulin resistance, decreased from 3·3 (1·9-5·5) to 0·7 (0·5-1·1) mg/dl·μunits/ml (P < 0·001). Total insulin secretion, measured as incremental area under the curve (AUC), after OGTT decreased from 360·4 (347·9-548·0) to 190·1 (10·1-252·0) mmol/l·180 min at 12 months (P = 0·011). The AUC for GLP-1 increased from 258·5 (97·5-552·6) to 5531·8 (4143·0-7540·9) pmol/l·180 min at 12 months after sleeve gastrectomy (P < 0·001). In multiple regression analysis, 51 per cent of the M-value variability was explained by GLP-1 secretion. Conclusion Sleeve gastrectomy improved insulin sensitivity and reduced insulin secretion within 6 months after surgery. Although there was a correlation between insulin sensitivity and bodyweight, the major driver of the improvement in insulin sensitivity was GLP-1 secretion. Improves insulin sensitivity, reduces insulin secretion
Lingua originaleEnglish
pagine (da-a)242-248
Numero di pagine7
RivistaBritish Journal of Surgery
Stato di pubblicazionePubblicato - 2016


  • Adult
  • Aged
  • Bariatric Surgery
  • Blood Glucose
  • Body Mass Index
  • Diabetes Mellitus, Type 2
  • Female
  • Gastrectomy
  • Glucose Tolerance Test
  • Humans
  • Insulin
  • Insulin Resistance
  • Male
  • Medicine (all)
  • Middle Aged
  • Obesity, Morbid
  • Surgery
  • Young Adult


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