Changes in bone mineral density in HIV-positive, virologically suppressed patients switching to lamivudine/dolutegravir dual therapy: preliminary results from clinical practice

Arturo Ciccullo; Alessandro D’Avino; Anna Pia Lassandro; Gianmaria Baldin; Alberto Borghetti; Alex Dusina; Arianna Emiliozzi; Roberta Gagliardini; Davide Moschese; Simone Belmonti; Francesca Lombardi; Simona Di Giambenedetto

Changes in bone mineral density in HIV-positive, virologically suppressed patients switching to lamivudine/dolutegravir dual therapy: preliminary results from clinical practice

Arturo Ciccullo, Alessandro D’Avino, Anna Pia Lassandro, Gianmaria Baldin, Alberto Borghetti, Alex Dusina, Arianna Emiliozzi, Roberta Gagliardini, Davide Moschese, Simone Belmonti, Francesca Lombardi, Simona Di Giambenedetto

Risultato della ricerca: Contributo in rivista › Articolo in rivista

9 Citazioni (Scopus)

Abstract

Bone toxicity is a well-known side effect of several antiviral agents. In a cohort of virologically suppressed HIV-infected patients, we investigated the effects of a lamivudine/dolutegravir dual therapy on bone mineral density (BMD). We observed a significant improvement in lumbar spine BMD as well as T-score after 12 months of observation with concomitant bisphosphonate therapy independently predicting a greater improvement. These preliminary data show a favorable effect of this 2-drug regimen on bone health.

Lingua originale	English
pagine (da-a)	336-340
Numero di pagine	5
Rivista	LE INFEZIONI IN MEDICINA
Volume	26
Stato di pubblicazione	Pubblicato - 2018

Keywords

Anti-HIV Agents
Bone Density
Drug Combinations
Drug Substitution
Female
HIV Infections
HIV Integrase Inhibitors
Heterocyclic Compounds, 3-Ring
Humans
Lamivudine
Male
Middle Aged
Retrospective Studies

OSS delle Nazioni Unite

Questo processo contribuisce al raggiungimento dei seguenti obiettivi di sviluppo sostenibile

Altri file e collegamenti

Link a IRIS PubliCatt

Cita questo

Ciccullo, A., D’Avino, A., Lassandro, A. P., Baldin, G., Borghetti, A., Dusina, A., Emiliozzi, A., Gagliardini, R., Moschese, D., Belmonti, S., Lombardi, F., & Di Giambenedetto, S. (2018). Changes in bone mineral density in HIV-positive, virologically suppressed patients switching to lamivudine/dolutegravir dual therapy: preliminary results from clinical practice. LE INFEZIONI IN MEDICINA, 26, 336-340.

@article{6f2b1cc8fd7a4a819c66a944a58518e3,

title = "Changes in bone mineral density in HIV-positive, virologically suppressed patients switching to lamivudine/dolutegravir dual therapy: preliminary results from clinical practice",

abstract = "Bone toxicity is a well-known side effect of several antiviral agents. In a cohort of virologically suppressed HIV-infected patients, we investigated the effects of a lamivudine/dolutegravir dual therapy on bone mineral density (BMD). We observed a significant improvement in lumbar spine BMD as well as T-score after 12 months of observation with concomitant bisphosphonate therapy independently predicting a greater improvement. These preliminary data show a favorable effect of this 2-drug regimen on bone health.",

keywords = "Anti-HIV Agents, Bone Density, Drug Combinations, Drug Substitution, Female, HIV Infections, HIV Integrase Inhibitors, Heterocyclic Compounds, 3-Ring, Humans, Lamivudine, Male, Middle Aged, Retrospective Studies, Anti-HIV Agents, Bone Density, Drug Combinations, Drug Substitution, Female, HIV Infections, HIV Integrase Inhibitors, Heterocyclic Compounds, 3-Ring, Humans, Lamivudine, Male, Middle Aged, Retrospective Studies",

author = "Arturo Ciccullo and Alessandro D{\textquoteright}Avino and Lassandro, {Anna Pia} and Gianmaria Baldin and Alberto Borghetti and Alex Dusina and Arianna Emiliozzi and Roberta Gagliardini and Davide Moschese and Simone Belmonti and Francesca Lombardi and {Di Giambenedetto}, Simona",

year = "2018",

language = "English",

volume = "26",

pages = "336--340",

journal = "LE INFEZIONI IN MEDICINA",

issn = "1124-9390",

publisher = "Roma: Els{\`e}v. Edizioni mediche.",

}

Ciccullo, A, D’Avino, A, Lassandro, AP, Baldin, G, Borghetti, A, Dusina, A, Emiliozzi, A, Gagliardini, R, Moschese, D, Belmonti, S, Lombardi, F & Di Giambenedetto, S 2018, 'Changes in bone mineral density in HIV-positive, virologically suppressed patients switching to lamivudine/dolutegravir dual therapy: preliminary results from clinical practice', LE INFEZIONI IN MEDICINA, vol. 26, pagg. 336-340.

Changes in bone mineral density in HIV-positive, virologically suppressed patients switching to lamivudine/dolutegravir dual therapy: preliminary results from clinical practice. / Ciccullo, Arturo; D’Avino, Alessandro; Lassandro, Anna Pia et al.
In: LE INFEZIONI IN MEDICINA, Vol. 26, 2018, pag. 336-340.

Risultato della ricerca: Contributo in rivista › Articolo in rivista

TY - JOUR

T1 - Changes in bone mineral density in HIV-positive, virologically suppressed patients switching to lamivudine/dolutegravir dual therapy: preliminary results from clinical practice

AU - Ciccullo, Arturo

AU - D’Avino, Alessandro

AU - Lassandro, Anna Pia

AU - Baldin, Gianmaria

AU - Borghetti, Alberto

AU - Dusina, Alex

AU - Emiliozzi, Arianna

AU - Gagliardini, Roberta

AU - Moschese, Davide

AU - Belmonti, Simone

AU - Lombardi, Francesca

AU - Di Giambenedetto, Simona

PY - 2018

Y1 - 2018

N2 - Bone toxicity is a well-known side effect of several antiviral agents. In a cohort of virologically suppressed HIV-infected patients, we investigated the effects of a lamivudine/dolutegravir dual therapy on bone mineral density (BMD). We observed a significant improvement in lumbar spine BMD as well as T-score after 12 months of observation with concomitant bisphosphonate therapy independently predicting a greater improvement. These preliminary data show a favorable effect of this 2-drug regimen on bone health.

AB - Bone toxicity is a well-known side effect of several antiviral agents. In a cohort of virologically suppressed HIV-infected patients, we investigated the effects of a lamivudine/dolutegravir dual therapy on bone mineral density (BMD). We observed a significant improvement in lumbar spine BMD as well as T-score after 12 months of observation with concomitant bisphosphonate therapy independently predicting a greater improvement. These preliminary data show a favorable effect of this 2-drug regimen on bone health.

KW - Anti-HIV Agents

KW - Bone Density

KW - Drug Combinations

KW - Drug Substitution

KW - Female

KW - HIV Infections

KW - HIV Integrase Inhibitors

KW - Heterocyclic Compounds, 3-Ring

KW - Humans

KW - Lamivudine

KW - Male

KW - Middle Aged

KW - Retrospective Studies

KW - Anti-HIV Agents

KW - Bone Density

KW - Drug Combinations

KW - Drug Substitution

KW - Female

KW - HIV Infections

KW - HIV Integrase Inhibitors

KW - Heterocyclic Compounds, 3-Ring

KW - Humans

KW - Lamivudine

KW - Male

KW - Middle Aged

KW - Retrospective Studies

UR - http://hdl.handle.net/10807/140090

M3 - Article

SN - 1124-9390

VL - 26

SP - 336

EP - 340

JO - LE INFEZIONI IN MEDICINA

JF - LE INFEZIONI IN MEDICINA

ER -

Changes in bone mineral density in HIV-positive, virologically suppressed patients switching to lamivudine/dolutegravir dual therapy: preliminary results from clinical practice

Abstract

Keywords

OSS delle Nazioni Unite

Altri file e collegamenti

Fingerprint

Cita questo