TY - JOUR
T1 - Challenges and opportunities for international cooperative studies in pediatric hematopoeitic cell transplantation: priorities of the Westhafen Intercontinental Group
AU - Schultz, Rudolph Kirk R.
AU - Baker, Kevin Scott
AU - Boelens, Jaap J.
AU - Bollard, Catherine M.
AU - Egeler, R. Maarten
AU - Cowan, Mort
AU - Ladenstein, Ruth
AU - Lankester, Arjan
AU - Locatelli, Franco
AU - Lawitschka, Anita
AU - Levine, John E.
AU - Loh, Mignon
AU - Nemecek, Eneida
AU - Niemeyer, Charlotte
AU - Prasad, Vinod K.
AU - Rocha, Vanderson
AU - Shenoy, Shalini
AU - Strahm, Brigitte
AU - Veys, Paul
AU - Wall, Donna
AU - Bader, Peter
AU - Grupp, Stephan A.
AU - Pulsipher, Michael A.
AU - Peters, Christina
PY - 2013
Y1 - 2013
N2 - More than 20% of allogeneic hematopoietic cell transplantations (HCTs) are performed in children and adolescents at a large number of relatively small centers. Unlike adults, at least one-third of HCTs in children are performed for rare, nonmalignant indications. Clinical trials to improve HCT outcomes in children have been limited by small numbers and these pediatric-specific features. The need for a larger number of pediatric HCT centers to participate in trials has led to the involvement of international collaborative groups. Representatives of the Pediatric Blood and Marrow Transplant Consortium, European Group for Blood and Marrow Transplantation's Pediatric Working Group, International Berlin-Frankfurt-Munster (iBFm) Stem Cell Transplantation Committee, and Children's Oncology Group's Hematopoietic Stem Cell Transplantation Discipline Committee met on October 3, 2012, in Frankfurt, Germany to develop a consensus on the highest priorities in pediatric HCT. In addition, it explored the creation of an international consortium to develop studies focused on HCT in children and adolescents. This meeting led to the creation of an international HCT network, dubbed the Westhafen Intercontinental Group, to develop worldwide priorities and strategies to address pediatric HCT issues. This review outlines the priorities of need as identified by this consensus group. (C) 2013 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.
AB - More than 20% of allogeneic hematopoietic cell transplantations (HCTs) are performed in children and adolescents at a large number of relatively small centers. Unlike adults, at least one-third of HCTs in children are performed for rare, nonmalignant indications. Clinical trials to improve HCT outcomes in children have been limited by small numbers and these pediatric-specific features. The need for a larger number of pediatric HCT centers to participate in trials has led to the involvement of international collaborative groups. Representatives of the Pediatric Blood and Marrow Transplant Consortium, European Group for Blood and Marrow Transplantation's Pediatric Working Group, International Berlin-Frankfurt-Munster (iBFm) Stem Cell Transplantation Committee, and Children's Oncology Group's Hematopoietic Stem Cell Transplantation Discipline Committee met on October 3, 2012, in Frankfurt, Germany to develop a consensus on the highest priorities in pediatric HCT. In addition, it explored the creation of an international consortium to develop studies focused on HCT in children and adolescents. This meeting led to the creation of an international HCT network, dubbed the Westhafen Intercontinental Group, to develop worldwide priorities and strategies to address pediatric HCT issues. This review outlines the priorities of need as identified by this consensus group. (C) 2013 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.
KW - Pediatrics
KW - Hematopoietic cell transplantation
KW - Pediatrics
KW - Hematopoietic cell transplantation
UR - http://hdl.handle.net/10807/244414
U2 - 10.1016/j.bbmt.2013.07.006
DO - 10.1016/j.bbmt.2013.07.006
M3 - Article
SN - 1523-6536
VL - 19
SP - 1279
EP - 1287
JO - Biology of Blood and Marrow Transplantation
JF - Biology of Blood and Marrow Transplantation
ER -