Cessation of alcohol drinking, tobacco smoking and the reversal of head and neck cancer risk

Gabriella Cadoni, Stefania Boccia, Manuela Marron, Paolo Boffetta, Zuo-Feng Zhang, David Zaridze, Victor Wünsch-Filho, Deborah M. Winn, Qingyi Wei, Renato Talamini, Neonila Szeszenia-Dabrowska, Erich M. Sturgis, Elaine Smith, Stephen M. Schwartz, Peter Rudnai, Mark P. Purdue, Andrew F. Olshan, Jose Eluf-Neto, Joshua Muscat, Hal MorgensternAna Menezes, Michael Mcclean, Elena Matos, Ioan Nicolae Mates, Jolanta Lissowska, Fabio Levi, Philip Lazarus, Carlo La Vecchia, Sergio Koifman, Karl Kelsey, Rolando Herrero, Richard B. Hayes, Silvia Franceschi, Leticia Fernandez, Eleonora Fabianova, Alexander W. Daudt, Luigino Dal Maso, Maria Paula Curado, Chu Chen, Xavier Castellsague, Simone Benhamou, Gilles Ferro, Julien Berthiller, Paul Brennan, Henrik Møller, Mia Hashibe

Risultato della ricerca: Contributo in rivistaArticolo in rivista

140 Citazioni (Scopus)

Abstract

BACKGROUND: Quitting tobacco or alcohol use has been reported to reduce the head and neck cancer risk in previous studies. However, it is unclear how many years must pass following cessation of these habits before the risk is reduced, and whether the risk ultimately declines to the level of never smokers or never drinkers. METHODS: We pooled individual-level data from case-control studies in the International Head and Neck Cancer Epidemiology Consortium. Data were available from 13 studies on drinking cessation (9167 cases and 12 593 controls), and from 17 studies on smoking cessation (12 040 cases and 16 884 controls). We estimated the effect of quitting smoking and drinking on the risk of head and neck cancer and its subsites, by calculating odds ratios (ORs) using logistic regression models. RESULTS: Quitting tobacco smoking for 1-4 years resulted in a head and neck cancer risk reduction [OR 0.70, confidence interval (CI) 0.61-0.81 compared with current smoking], with the risk reduction due to smoking cessation after > or =20 years (OR 0.23, CI 0.18-0.31), reaching the level of never smokers. For alcohol use, a beneficial effect on the risk of head and neck cancer was only observed after > or =20 years of quitting (OR 0.60, CI 0.40-0.89 compared with current drinking), reaching the level of never drinkers. CONCLUSIONS: Our results support that cessation of tobacco smoking and cessation of alcohol drinking protect against the development of head and neck cancer
Lingua originaleEnglish
pagine (da-a)182-196
Numero di pagine15
RivistaInternational Journal of Epidemiology
Stato di pubblicazionePubblicato - 2010

Keywords

  • Epidemiology
  • alcohol drinking
  • cessation
  • head and neck cancer
  • tobacco smoking

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