Cervical extramedullary lymphomatoid granulomatosis

Nicola Montano*, Marco Lucantoni, Luigi Maria Larocca, Fabio Papacci, Mario Meglio

*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivistaArticolo in rivista

1 Citazioni (Scopus)


Lymphomatoid granulomatosis (LYG) is a rare multisystem disease involving most frequently the lung, kidney and skin. LYG is characterized by an infiltration of atypical lymphocytoid and plasmocytoid cells, with granulomatous inflammation in an angiocentric and angiodestructive pattern. There have been only a few reports of spinal involvement of LYG. To our knowledge, we report the first patient with cervical extramedullary LYG undergoing surgical removal of a lesion causing spinal cord compression, and review the pertinent literature. The patient underwent C5-partial T1 laminectomy with partial removal of the lesion and decompression of the spinal cord. A diagnosis of a grade III LYG was made and chemotherapy with cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) was administered. The patient was in good neurological condition at the 6-month follow-up but died 5 months later because of systemic progression of the disease. Although prognosis of LYG remains poor, surgery can be considered to improve pain relief and neurological morbidity of spinal LYG. © 2010 Elsevier Ltd. All rights reserved.
Lingua originaleEnglish
pagine (da-a)851-853
Numero di pagine3
RivistaJournal of Clinical Neuroscience
Stato di pubblicazionePubblicato - 2011


  • Lymphomatoid granulomatosis
  • MRI
  • Spinal cord


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