Cerebrospinal fluid free light chains compared to oligoclonal bands as biomarkers in multiple sclerosis

Lorenzo Gaetani; Marinella Di Carlo; Giovanni Brachelente; Federico Valletta; Paolo Eusebi; Andrea Mancini; Lucia Gentili; Angela Borrelli; Paolo Calabresi; Paola Sarchielli; Carla Ferri; Alfredo Villa; Massimiliano Di Filippo

doi:10.1016/j.jneuroim.2019.577108

Cerebrospinal fluid free light chains compared to oligoclonal bands as biomarkers in multiple sclerosis

Lorenzo Gaetani, Marinella Di Carlo, Giovanni Brachelente, Federico Valletta, Paolo Eusebi, Andrea Mancini, Lucia Gentili, Angela Borrelli, Paolo Calabresi, Paola Sarchielli, Carla Ferri, Alfredo Villa, Massimiliano Di Filippo

Risultato della ricerca: Contributo in rivista › Articolo in rivista

5 Citazioni (Scopus)

Abstract

Cerebrospinal fluid (CSF) free light chains (FLC) may be an alternative biomarker to oligoclonal bands (OCB) in multiple sclerosis (MS). Herein, we compared the diagnostic accuracy of CSF OCB and FLC and we tested the prognostic value of FLC in a cohort of 64 MS patients and 106 controls. A κ-index >7.83 was more sensitive but less specific than OCB in discriminating MS patients from controls. Additionally, a κ-index >10.61 performed better than OCB in the discrimination between MS and controls with inflammatory neurological diseases (p <.001). In clinically isolated syndrome (CIS) patients, a κ-index >10.61 significantly predicted time to conversion to MS (p =.020). κ-index might be a valid alternative to OCB as a diagnostic biomarker for MS and might also be a prognostic marker in CIS.

Lingua originale	English
pagine (da-a)	N/A-N/A
Rivista	Journal of Neuroimmunology
Volume	339
DOI	https://doi.org/10.1016/j.jneuroim.2019.577108
Stato di pubblicazione	Pubblicato - 2020

Keywords

Biomarker
Cerebrospinal fluid
Free light chains
Kappa index
Multiple sclerosis

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10.1016/j.jneuroim.2019.577108

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Gaetani, L., Di Carlo, M., Brachelente, G., Valletta, F., Eusebi, P., Mancini, A., Gentili, L., Borrelli, A., Calabresi, P., Sarchielli, P., Ferri, C., Villa, A., & Di Filippo, M. (2020). Cerebrospinal fluid free light chains compared to oligoclonal bands as biomarkers in multiple sclerosis. Journal of Neuroimmunology, 339, N/A-N/A. https://doi.org/10.1016/j.jneuroim.2019.577108

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title = "Cerebrospinal fluid free light chains compared to oligoclonal bands as biomarkers in multiple sclerosis",

abstract = "Cerebrospinal fluid (CSF) free light chains (FLC) may be an alternative biomarker to oligoclonal bands (OCB) in multiple sclerosis (MS). Herein, we compared the diagnostic accuracy of CSF OCB and FLC and we tested the prognostic value of FLC in a cohort of 64 MS patients and 106 controls. A κ-index >7.83 was more sensitive but less specific than OCB in discriminating MS patients from controls. Additionally, a κ-index >10.61 performed better than OCB in the discrimination between MS and controls with inflammatory neurological diseases (p <.001). In clinically isolated syndrome (CIS) patients, a κ-index >10.61 significantly predicted time to conversion to MS (p =.020). κ-index might be a valid alternative to OCB as a diagnostic biomarker for MS and might also be a prognostic marker in CIS.",

keywords = "Biomarker, Cerebrospinal fluid, Free light chains, Kappa index, Multiple sclerosis, Biomarker, Cerebrospinal fluid, Free light chains, Kappa index, Multiple sclerosis",

author = "Lorenzo Gaetani and {Di Carlo}, Marinella and Giovanni Brachelente and Federico Valletta and Paolo Eusebi and Andrea Mancini and Lucia Gentili and Angela Borrelli and Paolo Calabresi and Paola Sarchielli and Carla Ferri and Alfredo Villa and {Di Filippo}, Massimiliano",

year = "2020",

doi = "10.1016/j.jneuroim.2019.577108",

language = "English",

volume = "339",

pages = "N/A--N/A",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Amsterdam ; Lausanne ; New York ; Oxford ; Shannon ; Tokyo : Elsevier",

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Gaetani, L, Di Carlo, M, Brachelente, G, Valletta, F, Eusebi, P, Mancini, A, Gentili, L, Borrelli, A, Calabresi, P, Sarchielli, P, Ferri, C, Villa, A & Di Filippo, M 2020, 'Cerebrospinal fluid free light chains compared to oligoclonal bands as biomarkers in multiple sclerosis', Journal of Neuroimmunology, vol. 339, pagg. N/A-N/A. https://doi.org/10.1016/j.jneuroim.2019.577108

TY - JOUR

T1 - Cerebrospinal fluid free light chains compared to oligoclonal bands as biomarkers in multiple sclerosis

AU - Gaetani, Lorenzo

AU - Di Carlo, Marinella

AU - Brachelente, Giovanni

AU - Valletta, Federico

AU - Eusebi, Paolo

AU - Mancini, Andrea

AU - Gentili, Lucia

AU - Borrelli, Angela

AU - Calabresi, Paolo

AU - Sarchielli, Paola

AU - Ferri, Carla

AU - Villa, Alfredo

AU - Di Filippo, Massimiliano

PY - 2020

Y1 - 2020

N2 - Cerebrospinal fluid (CSF) free light chains (FLC) may be an alternative biomarker to oligoclonal bands (OCB) in multiple sclerosis (MS). Herein, we compared the diagnostic accuracy of CSF OCB and FLC and we tested the prognostic value of FLC in a cohort of 64 MS patients and 106 controls. A κ-index >7.83 was more sensitive but less specific than OCB in discriminating MS patients from controls. Additionally, a κ-index >10.61 performed better than OCB in the discrimination between MS and controls with inflammatory neurological diseases (p <.001). In clinically isolated syndrome (CIS) patients, a κ-index >10.61 significantly predicted time to conversion to MS (p =.020). κ-index might be a valid alternative to OCB as a diagnostic biomarker for MS and might also be a prognostic marker in CIS.

AB - Cerebrospinal fluid (CSF) free light chains (FLC) may be an alternative biomarker to oligoclonal bands (OCB) in multiple sclerosis (MS). Herein, we compared the diagnostic accuracy of CSF OCB and FLC and we tested the prognostic value of FLC in a cohort of 64 MS patients and 106 controls. A κ-index >7.83 was more sensitive but less specific than OCB in discriminating MS patients from controls. Additionally, a κ-index >10.61 performed better than OCB in the discrimination between MS and controls with inflammatory neurological diseases (p <.001). In clinically isolated syndrome (CIS) patients, a κ-index >10.61 significantly predicted time to conversion to MS (p =.020). κ-index might be a valid alternative to OCB as a diagnostic biomarker for MS and might also be a prognostic marker in CIS.

KW - Biomarker

KW - Cerebrospinal fluid

KW - Free light chains

KW - Kappa index

KW - Multiple sclerosis

KW - Biomarker

KW - Cerebrospinal fluid

KW - Free light chains

KW - Kappa index

KW - Multiple sclerosis

UR - http://hdl.handle.net/10807/150379

U2 - 10.1016/j.jneuroim.2019.577108

DO - 10.1016/j.jneuroim.2019.577108

M3 - Article

SN - 0165-5728

VL - 339

SP - N/A-N/A

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

ER -

Cerebrospinal fluid free light chains compared to oligoclonal bands as biomarkers in multiple sclerosis

Abstract

Keywords

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