Cerebrospinal fluid and serum D-serine concentrations are unaltered across the whole clinical spectrum of Alzheimer's disease

Paolo Calabresi, Tommaso Nuzzo, Mattia Miroballo, Alessia Casamassa, Andrea Mancini, Lorenzo Gaetani, Robert Nisticò, Paolo Eusebi, Masumi Katane, Hiroshi Homma, Francesco Errico, Lucilla Parnetti, Alessandro Usiello

Risultato della ricerca: Contributo in rivistaArticolo in rivista

3 Citazioni (Scopus)

Abstract

The diagnosis of Alzheimer's disease (AD) relies on the presence of amyloidosis and tauopathy, as reflected in cerebrospinal fluid (CSF), independently from the clinical stage. Recently, CSF D-serine has been proposed as a possible new AD biomarker, reflecting dysfunctional activation of neuronal glutamatergic N-methyl-D-aspartate receptor (NMDAR). In this study, we measured blood serum and CSF concentration of two NMDAR modulators, such as D-serine and D-aspartate, in a cohort of drug-free subjects encompassing the whole AD clinical spectrum. In addition, we also analyzed D-serine levels in a cohort of post-mortem AD and control cortex samples. We reported unaltered serum and CSF concentrations of D-serine and D-aspartate in AD patients both during the AD progression and compared to non-demented controls. Accordingly, no correlation was detected between serum or CSF D-serine content and mini-mental state examination or Clinical Dementia Rating. Similarly, cortical D-serine levels were also unaltered in post-mortem samples of AD patients. Overall, our results failed to confirm previous findings indicating the CSF D-serine as a novel biomarker for AD.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaBIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
Volume2020
DOI
Stato di pubblicazionePubblicato - 2020

Keywords

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease
  • Alzheimer's disease
  • Amyloid beta-Peptides
  • Aspartic Acid
  • Biomarker
  • Biomarkers
  • Brain
  • D-amino acids
  • Dementia
  • Female
  • Humans
  • Male
  • Mild cognitive impairment
  • Organ Specificity
  • Postpartum Period
  • Prognosis
  • Serine
  • tau Proteins

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