Cerebellar degeneration associated with mGluR1 autoantibodies as a paraneoplastic manifestation of prostate adenocarcinoma

Valentina Damato, Massimiliano Mirabella, Raffaele Iorio, Maria Gabriella Vita, Domenico Plantone, Alessandra Bizzarro, Alessandra Del Grande, Esther Hulsenboom, Peter A.E. Sillevis Smitt

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

30 Citazioni (Scopus)

Abstract

Subacute cerebellar degeneration associated with metabotropic glutamate receptor type 1 (mGluR1) autoantibodies is an uncommon syndrome known to be part of the spectrum of paraneoplastic cerebellar degenerations associated with neuronal autoantibodies. We describe a patient with prostate adenocarcinoma who developed a subacute cerebellar ataxia. Autoantibodies specific to mGluR1 were detected in patient's serum and cerebrospinal fluid (CSF). Immunohistochemistry analyses of patient's prostate adenocarcinoma revealed abundant mGluR1 expression in luminal acinar epithelial cells and binding of patient's IgGs to tumoral mGluR1. These findings suggest that cerebellar degeneration associated with mGluR1 antibodies can be a paraneoplastic accompaniment of prostate adenocarcinoma.
Lingua originaleEnglish
pagine (da-a)155-158
Numero di pagine4
RivistaJournal of Neuroimmunology
Volume263
DOI
Stato di pubblicazionePubblicato - 2013

Keywords

  • Adenocarcinoma
  • Aged
  • Animals
  • Antibodies
  • Autoantibodies
  • Biological Markers
  • HEK293 Cells
  • Humans
  • Male
  • Metabotropic glutamate receptor 1
  • Mice
  • Paraneoplastic Cerebellar Degeneration
  • Paraneoplastic cerebellar degeneration
  • Prostatic Neoplasms
  • Receptors, Metabotropic Glutamate

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