Cerebellar ataxia and coenzyme Q10 deficiency

Serenella Servidei, C. Lamperti, A. Naini, M. Hirano, D. C. De Vivo, E. Bertini, M. Valeriani, D. Lynch, B. Banwell, M. Berg, T. Dubrovsky, C. Chiriboga, C. Angelini, E. Pegoraro, Salvatore Dimauro

Risultato della ricerca: Contributo in rivistaArticolo in rivista

162 Citazioni (Scopus)

Abstract

The authors measured coenzyme Q10 (CoQ10) concentration in muscle biopsies from 135 patients with genetically undefined cerebellar ataxia. Thirteen patients with childhood-onset ataxia and cerebellar atrophy had markedly decreased levels of CoQ10. Associated symptoms included seizures, developmental delay, mental retardation, and pyramidal signs. These findings confirm the existence of an ataxic presentation of CoQ10 deficiency, which may be responsive to CoQ10 supplementation.
Lingua originaleEnglish
pagine (da-a)1206-1208
Numero di pagine3
RivistaNeurology
Volume2003
DOI
Stato di pubblicazionePubblicato - 2003

Keywords

  • ataxia
  • coezyme Q10

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