Central conduction abnormalities in patients receiving levodopa-carbidopa intestinal gel infusion

Francesco Bove, Marco Luigetti, Riccardo Di Iorio, Alfonso Fasano, Lara Gallicchio, Valentina Recchia, Antonella Petruzzellis, Filippo Tamma

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

2 Citazioni (Scopus)

Abstract

In recent years, several studies have reported a relatively high frequency of polyneuropathy in patients with Parkinson’s disease (PD), in particular, in patients receiving levodopa-carbidopa intestinal gel (LCIG) infusion. In spite of the several patients investigated with nerve conduction studies, no study has prospectively explored a possible central nervous system involvement of patients receiving LCIG infusion. We prospectively evaluated eight PD patients receiving LCIG infusion, who underwent neurophysiological evaluations with nerve conduction studies, visual, somatosensory and motor evoked potentials before LCIG infusion, and 1 and 6 months after. At 6 months follow-up, we found significant reduction in sural nerve SNAP amplitude, increase of central sensory conduction time N22-P40, and increases of central motor conduction time recorded from I dorsal interosseous and tibialis anterior. In PD patients with LCIG infusion, we found a subclinical neurophysiological impairment of both peripheral and central nervous system.
Lingua originaleEnglish
pagine (da-a)1869-1872
Numero di pagine4
RivistaNeurological Sciences
Volume38
DOI
Stato di pubblicazionePubblicato - 2017

Keywords

  • 2708
  • Aged
  • Antiparkinson Agents
  • Carbidopa
  • Central Nervous System
  • Clinical neurophysiology
  • Drug Combinations
  • Electromyography (EMG)
  • Evoked potentials
  • Female
  • Follow-Up Studies
  • Gels
  • Humans
  • Infusions, Parenteral
  • Levodopa
  • Male
  • Neural Conduction
  • Neurology (clinical)
  • Neuropharmacology
  • Parkinson Disease
  • Parkinson’s disease
  • Peripheral Nervous System
  • Polyneuropathies
  • Prospective Studies
  • Psychiatry and Mental Health

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