Cellular stress marker alteration and inflammatory response in pigs fed with an ochratoxin contaminated diet

Terenzio Bertuzzi, Chiara Bernardini, Ester Grilli, Johanna Catharina Duvigneau, Augusta Zannoni, Benedetta Tugnoli, Fabio Gentilini, Silvia Spinozzi, Cecilia Camborata, Maria Laura Bacci, Andrea Piva, Monica Forni

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13 Citazioni (Scopus)

Abstract

on growth performances, blood parameters, systemic cytokine levels, cell stress markers and reactivity of immune system of weaned pigs. Growth performance was not affected by OTA consumption even if OTA levels increased in plasma, kidney and liver. OTA diminished the protein content in the serum and increased levels of TNF-alpha and IL-10 in plasma. HO-1 mRNA, indicative for cells stress, was decreased in the kidney but increased in the liver. Additionally, whole blood of the animals of the OTA-group showed a decreased capacity to respond with cytokine expression (mRNA and protein) to ex vivo challenge with LPS. In conclusion our findings indicate that chronic ingestion with OTA-contaminated feed, even at low level, is hazardous for the animal and virtually for human health, pig being an excellent model for human.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaResearch in Veterinary Science
Volume2015
DOI
Stato di pubblicazionePubblicato - 2014

Keywords

  • OTA, PIG

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