TY - JOUR
T1 - Cellular stress marker alteration and inflammatory response in pigs
fed with an ochratoxin contaminated diet
AU - Bertuzzi, Terenzio
AU - Bernardini, Chiara
AU - Grilli, Ester
AU - Duvigneau, Catharina
AU - Zannoni, Augusta
AU - Tugnoli, Benedetta
AU - Gentilini, Fabio
AU - Spinozzi, Silvia
AU - Camborata, Cecilia
AU - Bacci, Maria Laura
AU - Piva, Andrea
AU - Forni, Monica
PY - 2014
Y1 - 2014
N2 - on growth performances, blood parameters, systemic cytokine levels, cell stress markers and reactivity\r\nof immune system of weaned pigs.\r\nGrowth performance was not affected by OTA consumption even if OTA levels increased in plasma,\r\nkidney and liver. OTA diminished the protein content in the serum and increased levels of TNF-alpha\r\nand IL-10 in plasma. HO-1 mRNA, indicative for cells stress, was decreased in the kidney but increased\r\nin the liver. Additionally, whole blood of the animals of the OTA-group showed a decreased capacity to\r\nrespond with cytokine expression (mRNA and protein) to ex vivo challenge with LPS. In conclusion our\r\nfindings indicate that chronic ingestion with OTA-contaminated feed, even at low level, is hazardous for\r\nthe animal and virtually for human health, pig being an excellent model for human.
AB - on growth performances, blood parameters, systemic cytokine levels, cell stress markers and reactivity\r\nof immune system of weaned pigs.\r\nGrowth performance was not affected by OTA consumption even if OTA levels increased in plasma,\r\nkidney and liver. OTA diminished the protein content in the serum and increased levels of TNF-alpha\r\nand IL-10 in plasma. HO-1 mRNA, indicative for cells stress, was decreased in the kidney but increased\r\nin the liver. Additionally, whole blood of the animals of the OTA-group showed a decreased capacity to\r\nrespond with cytokine expression (mRNA and protein) to ex vivo challenge with LPS. In conclusion our\r\nfindings indicate that chronic ingestion with OTA-contaminated feed, even at low level, is hazardous for\r\nthe animal and virtually for human health, pig being an excellent model for human.
KW - OTA
KW - PIG
KW - OTA
KW - PIG
UR - https://publicatt.unicatt.it/handle/10807/61454
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84925047070&origin=inward
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84925047070&origin=inward
U2 - 10.1016/j.rvsc.2014.07.018
DO - 10.1016/j.rvsc.2014.07.018
M3 - Article
SN - 0034-5288
VL - 97
SP - 244
EP - 250
JO - Research in Veterinary Science
JF - Research in Veterinary Science
IS - 2
ER -