Cellular stress marker alteration and inflammatory response in pigs fed with an ochratoxin contaminated diet

Terenzio Bertuzzi, Chiara Bernardini*, Ester Grilli, Catharina Duvigneau, Augusta Zannoni, Benedetta Tugnoli, Fabio Gentilini, Silvia Spinozzi, Cecilia Camborata, Maria Laura Bacci, Andrea Piva, Monica Forni

*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivistaArticolopeer review

13 Citazioni (Scopus)

Abstract

on growth performances, blood parameters, systemic cytokine levels, cell stress markers and reactivity\r\nof immune system of weaned pigs.\r\nGrowth performance was not affected by OTA consumption even if OTA levels increased in plasma,\r\nkidney and liver. OTA diminished the protein content in the serum and increased levels of TNF-alpha\r\nand IL-10 in plasma. HO-1 mRNA, indicative for cells stress, was decreased in the kidney but increased\r\nin the liver. Additionally, whole blood of the animals of the OTA-group showed a decreased capacity to\r\nrespond with cytokine expression (mRNA and protein) to ex vivo challenge with LPS. In conclusion our\r\nfindings indicate that chronic ingestion with OTA-contaminated feed, even at low level, is hazardous for\r\nthe animal and virtually for human health, pig being an excellent model for human.
Lingua originaleInglese
pagine (da-a)244-250
RivistaResearch in Veterinary Science
Volume97
Numero di pubblicazione2
DOI
Stato di pubblicazionePubblicato - 2014

All Science Journal Classification (ASJC) codes

  • Veterinaria Generale

Keywords

  • OTA
  • PIG

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