Cellular protection from oxidative stress by the blood orange pigment cyanidin-3-O-beta-glucopyranoside

Angela Maria Amorini; G Fazzina; Giuseppe Lazzarino; Barbara Tavazzi; F Galvano; G. Galvano

Cellular protection from oxidative stress by the blood orange pigment cyanidin-3-O-beta-glucopyranoside

Angela Maria Amorini, G Fazzina, Giuseppe Lazzarino, Barbara Tavazzi, F Galvano, G. Galvano

Università Cattolica del Sacro Cuore

Risultato della ricerca: Contributo in libro › Contributo a convegno

Abstract

The cyanidin-3-O--glucopyranoside (C-3-G) antioxidant effects were assessed in two models of increased oxidative stress. Isolated post-ischemic rat heart reperfused with C-3-G showed inhibition of malondialdehyde (MDA) formation (-67% and -94% in 10 and 30 M C-3-G-reperfused hearts, respectively) and improved energy metabolism. Normoxic hearts perfused in the recirculating Langendorff mode with 10 and 30 M C-3-G indicated that C-3-G can permeate within myocardial cells. Dose-dependent decrease of MDA generation by C-3-G was observed in 2 mM H2O2-treated human erythrocytes (apparent IC50 of 5.12 M and 38.43 M were calculated for C-3-G and resveratrol, respectively). In conclusion, C-3-G (largely present also in pigmented oranges) may have beneficial effects in case of increased oxidative stress.

Lingua originale	English
Titolo della pubblicazione ospite	Proceeding of the 11th Biennial Meeting of the Society for Free Radical Research International.
Pagine	547-550
Numero di pagine	4
Stato di pubblicazione	Pubblicato - 2002
Evento	11th Biennial Meeting of the Society for Free Radical Research International. - Parigi Durata: 3 lug 2002 → 7 lug 2002

Convegno

Convegno	11th Biennial Meeting of the Society for Free Radical Research International.
Città	Parigi
Periodo	3/7/02 → 7/7/02

Keywords

Cyanidin-3-O-beta-glucopyranoside

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@inproceedings{155dd097dce44cccb6aa39d285e7a0ee,

title = "Cellular protection from oxidative stress by the blood orange pigment cyanidin-3-O-beta-glucopyranoside",

abstract = "The cyanidin-3-O--glucopyranoside (C-3-G) antioxidant effects were assessed in two models of increased oxidative stress. Isolated post-ischemic rat heart reperfused with C-3-G showed inhibition of malondialdehyde (MDA) formation (-67% and -94% in 10 and 30 M C-3-G-reperfused hearts, respectively) and improved energy metabolism. Normoxic hearts perfused in the recirculating Langendorff mode with 10 and 30 M C-3-G indicated that C-3-G can permeate within myocardial cells. Dose-dependent decrease of MDA generation by C-3-G was observed in 2 mM H2O2-treated human erythrocytes (apparent IC50 of 5.12 M and 38.43 M were calculated for C-3-G and resveratrol, respectively). In conclusion, C-3-G (largely present also in pigmented oranges) may have beneficial effects in case of increased oxidative stress.",

keywords = "Cyanidin-3-O-beta-glucopyranoside, Cyanidin-3-O-beta-glucopyranoside",

author = "Amorini, {Angela Maria} and G Fazzina and Giuseppe Lazzarino and Barbara Tavazzi and F Galvano and G. Galvano",

year = "2002",

language = "English",

pages = "547--550",

booktitle = "Proceeding of the 11th Biennial Meeting of the Society for Free Radical Research International.",

note = "11th Biennial Meeting of the Society for Free Radical Research International. ; Conference date: 03-07-2002 Through 07-07-2002",

}

Amorini, AM, Fazzina, G, Lazzarino, G, Tavazzi, B, Galvano, F & Galvano, G 2002, Cellular protection from oxidative stress by the blood orange pigment cyanidin-3-O-beta-glucopyranoside. in Proceeding of the 11th Biennial Meeting of the Society for Free Radical Research International.. pagg. 547-550, 11th Biennial Meeting of the Society for Free Radical Research International., Parigi, 3/7/02.

TY - GEN

T1 - Cellular protection from oxidative stress by the blood orange pigment cyanidin-3-O-beta-glucopyranoside

AU - Amorini, Angela Maria

AU - Fazzina, G

AU - Lazzarino, Giuseppe

AU - Tavazzi, Barbara

AU - Galvano, F

AU - Galvano, G.

PY - 2002

Y1 - 2002

N2 - The cyanidin-3-O--glucopyranoside (C-3-G) antioxidant effects were assessed in two models of increased oxidative stress. Isolated post-ischemic rat heart reperfused with C-3-G showed inhibition of malondialdehyde (MDA) formation (-67% and -94% in 10 and 30 M C-3-G-reperfused hearts, respectively) and improved energy metabolism. Normoxic hearts perfused in the recirculating Langendorff mode with 10 and 30 M C-3-G indicated that C-3-G can permeate within myocardial cells. Dose-dependent decrease of MDA generation by C-3-G was observed in 2 mM H2O2-treated human erythrocytes (apparent IC50 of 5.12 M and 38.43 M were calculated for C-3-G and resveratrol, respectively). In conclusion, C-3-G (largely present also in pigmented oranges) may have beneficial effects in case of increased oxidative stress.

AB - The cyanidin-3-O--glucopyranoside (C-3-G) antioxidant effects were assessed in two models of increased oxidative stress. Isolated post-ischemic rat heart reperfused with C-3-G showed inhibition of malondialdehyde (MDA) formation (-67% and -94% in 10 and 30 M C-3-G-reperfused hearts, respectively) and improved energy metabolism. Normoxic hearts perfused in the recirculating Langendorff mode with 10 and 30 M C-3-G indicated that C-3-G can permeate within myocardial cells. Dose-dependent decrease of MDA generation by C-3-G was observed in 2 mM H2O2-treated human erythrocytes (apparent IC50 of 5.12 M and 38.43 M were calculated for C-3-G and resveratrol, respectively). In conclusion, C-3-G (largely present also in pigmented oranges) may have beneficial effects in case of increased oxidative stress.

KW - Cyanidin-3-O-beta-glucopyranoside

UR - http://hdl.handle.net/10807/16171

M3 - Conference contribution

SP - 547

EP - 550

BT - Proceeding of the 11th Biennial Meeting of the Society for Free Radical Research International.

T2 - 11th Biennial Meeting of the Society for Free Radical Research International.

Y2 - 3 July 2002 through 7 July 2002

ER -

Cellular protection from oxidative stress by the blood orange pigment cyanidin-3-O-beta-glucopyranoside

Abstract

Convegno

Keywords

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