Cellular protection from oxidative stress by the blood orange pigment cyanidin-3-O-beta-glucopyranoside

Barbara Tavazzi, Angela Maria Amorini, G Fazzina, Giuseppe Lazzarino, F Galvano, G. Galvano

Risultato della ricerca: Contributo in libroContributo a convegno

Abstract

The cyanidin-3-O--glucopyranoside (C-3-G) antioxidant effects were assessed in two models of increased oxidative stress. Isolated post-ischemic rat heart reperfused with C-3-G showed inhibition of malondialdehyde (MDA) formation (-67% and -94% in 10 and 30 M C-3-G-reperfused hearts, respectively) and improved energy metabolism. Normoxic hearts perfused in the recirculating Langendorff mode with 10 and 30 M C-3-G indicated that C-3-G can permeate within myocardial cells. Dose-dependent decrease of MDA generation by C-3-G was observed in 2 mM H2O2-treated human erythrocytes (apparent IC50 of 5.12 M and 38.43 M were calculated for C-3-G and resveratrol, respectively). In conclusion, C-3-G (largely present also in pigmented oranges) may have beneficial effects in case of increased oxidative stress.
Lingua originaleEnglish
Titolo della pubblicazione ospiteProceeding of the 11th Biennial Meeting of the Society for Free Radical Research International.
Pagine547-550
Numero di pagine4
Stato di pubblicazionePubblicato - 2002
Evento11th Biennial Meeting of the Society for Free Radical Research International. - Parigi
Durata: 3 lug 20027 lug 2002

Convegno

Convegno11th Biennial Meeting of the Society for Free Radical Research International.
CittàParigi
Periodo3/7/027/7/02

Keywords

  • Cyanidin-3-O-beta-glucopyranoside

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