Cellular Mechanisms of Cardioprotection by Calorie Restriction: State of the Science and Future Perspectives

Emanuele Marzetti, Roberto Bernabei, Stephanie E. Wohlgemuth, Stephen D. Anton, Christy S. Carter, Christiaan Leeuwenburgh

Risultato della ricerca: Contributo in rivistaArticolo in rivista

43 Citazioni (Scopus)

Abstract

Evidence from animal models and preliminary studies in humans indicates that calorie restriction (CR) delays cardiac aging and can prevent cardiovascular disease. These effects are mediated by a wide spectrum of biochemical and cellular adaptations, including redox homeostasis, mitochondrial function, inflammation, apoptosis, and autophagy. Despite the beneficial effects of CR, its large-scale implementation is challenged by applicability issues as well as health concerns. However, preclinical studies indicate that specific compounds, such as resveratrol, may mimic many of the effects of CR, thus potentially obviating the need for drastic food intake reductions. Results from ongoing clinical trials will reveal whether the intriguing alternative of CR mimetics represents a safe and effective strategy to promote cardiovascular health and delay cardiac aging in humans.
Lingua originaleEnglish
pagine (da-a)715-732
Numero di pagine18
RivistaClinics in Geriatric Medicine
Volume25
DOI
Stato di pubblicazionePubblicato - 2009

Keywords

  • Apoptosis
  • Autophagy
  • Calorie restriction mimetics
  • Cardiovascular disease
  • Inflammation
  • Oxidative stress

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