Cell death in acromegalic cardiomyopathy

Andrea Frustaci; C Chimenti; M Setoguchi; S Guerra; Salvatore Maria Corsello; Filippo Crea; A Leri; J Kajstura; P Anversa; A. Maseri

Cell death in acromegalic cardiomyopathy

Andrea Frustaci, C Chimenti, M Setoguchi, S Guerra, Salvatore Maria Corsello, Filippo Crea, A Leri, J Kajstura, P Anversa, A. Maseri

Risultato della ricerca: Contributo in rivista › Articolo in rivista

100 Citazioni (Scopus)

Abstract

Prolonged untreated acromegaly leads to a nonspecific myopathy characterized by ventricular dysfunction and failure. However, the mechanisms responsible for the alterations of cardiac pump function remain to be defined. Because cell death is implicated in most cardiac disease processes, the possibility has been raised that myocyte apoptosis may occur in the acromegalic heart, contributing to the deterioration of ventricular hemodynamics.

Lingua originale	English
pagine (da-a)	1426-1434
Numero di pagine	9
Rivista	Circulation
Volume	99
Stato di pubblicazione	Pubblicato - 1999

Keywords

Acromegaly
Adult
Aged
Apoptosis
Cell Death
Collagen
Diastole
Endomyocardial Fibrosis
Female
Heart Failure
Human Growth Hormone
Humans
Hypertrophy, Left Ventricular
Insulin-Like Growth Factor I
Male
Microscopy, Confocal
Middle Aged
Mitral Valve Stenosis
Myocardium
Necrosis
Papillary Muscles
Stroke Volume
Ventricular Dysfunction, Left

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title = "Cell death in acromegalic cardiomyopathy",

abstract = "Prolonged untreated acromegaly leads to a nonspecific myopathy characterized by ventricular dysfunction and failure. However, the mechanisms responsible for the alterations of cardiac pump function remain to be defined. Because cell death is implicated in most cardiac disease processes, the possibility has been raised that myocyte apoptosis may occur in the acromegalic heart, contributing to the deterioration of ventricular hemodynamics.",

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author = "Andrea Frustaci and C Chimenti and M Setoguchi and S Guerra and Corsello, {Salvatore Maria} and Filippo Crea and A Leri and J Kajstura and P Anversa and A. Maseri",

year = "1999",

language = "English",

volume = "99",

pages = "1426--1434",

journal = "Circulation",

issn = "0009-7322",

publisher = "Philadelphia, PA: Lippincott, Williams & Wilkins",

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TY - JOUR

T1 - Cell death in acromegalic cardiomyopathy

AU - Frustaci, Andrea

AU - Chimenti, C

AU - Setoguchi, M

AU - Guerra, S

AU - Corsello, Salvatore Maria

AU - Crea, Filippo

AU - Leri, A

AU - Kajstura, J

AU - Anversa, P

AU - Maseri, A.

PY - 1999

Y1 - 1999

N2 - Prolonged untreated acromegaly leads to a nonspecific myopathy characterized by ventricular dysfunction and failure. However, the mechanisms responsible for the alterations of cardiac pump function remain to be defined. Because cell death is implicated in most cardiac disease processes, the possibility has been raised that myocyte apoptosis may occur in the acromegalic heart, contributing to the deterioration of ventricular hemodynamics.

AB - Prolonged untreated acromegaly leads to a nonspecific myopathy characterized by ventricular dysfunction and failure. However, the mechanisms responsible for the alterations of cardiac pump function remain to be defined. Because cell death is implicated in most cardiac disease processes, the possibility has been raised that myocyte apoptosis may occur in the acromegalic heart, contributing to the deterioration of ventricular hemodynamics.

KW - Acromegaly

KW - Adult

KW - Aged

KW - Apoptosis

KW - Cell Death

KW - Collagen

KW - Diastole

KW - Endomyocardial Fibrosis

KW - Female

KW - Heart Failure

KW - Human Growth Hormone

KW - Humans

KW - Hypertrophy, Left Ventricular

KW - Insulin-Like Growth Factor I

KW - Male

KW - Microscopy, Confocal

KW - Middle Aged

KW - Mitral Valve Stenosis

KW - Myocardium

KW - Necrosis

KW - Papillary Muscles

KW - Stroke Volume

KW - Ventricular Dysfunction, Left

KW - Acromegaly

KW - Adult

KW - Aged

KW - Apoptosis

KW - Cell Death

KW - Collagen

KW - Diastole

KW - Endomyocardial Fibrosis

KW - Female

KW - Heart Failure

KW - Human Growth Hormone

KW - Humans

KW - Hypertrophy, Left Ventricular

KW - Insulin-Like Growth Factor I

KW - Male

KW - Microscopy, Confocal

KW - Middle Aged

KW - Mitral Valve Stenosis

KW - Myocardium

KW - Necrosis

KW - Papillary Muscles

KW - Stroke Volume

KW - Ventricular Dysfunction, Left

UR - http://hdl.handle.net/10807/13862

M3 - Article

SN - 0009-7322

VL - 99

SP - 1426

EP - 1434

JO - Circulation

JF - Circulation

ER -

Cell death in acromegalic cardiomyopathy

Abstract

Keywords

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