Cell death in acromegalic cardiomyopathy

Andrea Frustaci, C Chimenti, M Setoguchi, S Guerra, Salvatore Maria Corsello, Filippo Crea, A Leri, J Kajstura, P Anversa, A. Maseri

Risultato della ricerca: Contributo in rivistaArticolo in rivista

100 Citazioni (Scopus)


Prolonged untreated acromegaly leads to a nonspecific myopathy characterized by ventricular dysfunction and failure. However, the mechanisms responsible for the alterations of cardiac pump function remain to be defined. Because cell death is implicated in most cardiac disease processes, the possibility has been raised that myocyte apoptosis may occur in the acromegalic heart, contributing to the deterioration of ventricular hemodynamics.
Lingua originaleEnglish
pagine (da-a)1426-1434
Numero di pagine9
Stato di pubblicazionePubblicato - 1999


  • Acromegaly
  • Adult
  • Aged
  • Apoptosis
  • Cell Death
  • Collagen
  • Diastole
  • Endomyocardial Fibrosis
  • Female
  • Heart Failure
  • Human Growth Hormone
  • Humans
  • Hypertrophy, Left Ventricular
  • Insulin-Like Growth Factor I
  • Male
  • Microscopy, Confocal
  • Middle Aged
  • Mitral Valve Stenosis
  • Myocardium
  • Necrosis
  • Papillary Muscles
  • Stroke Volume
  • Ventricular Dysfunction, Left


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