Cdk4/6 inhibitor treatments in patients with hormone receptor positive, her2 negative advanced breast cancer: Potential molecular mechanisms, clinical implications and future perspectives

Antonio Astone, Alessandra Cassano, Armando Orlandi, Ida Paris, Michela Roberto, Andrea Botticelli, Giuliana D’Auria, Agnese Fabbri, Alessandra Fabi, Teresa Gamucci, Eriseld Krasniqi, Mauro Minelli, Francesco Pantano, Laura Pizzuti, Ilaria Portarena, Nello Salesi, Simone Scagnoli, Paola Scavina, Giuseppe Tonini, Patrizia ViciPaolo Marchetti

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

Abstract

Hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer is the most common breast cancer subtype, and endocrine therapy (ET) remains its therapeutic backbone. Although anti-estrogen therapies are usually effective initially, approximately 50% of HR+ patients develop resistance to ET within their lifetime, ultimately leading to disease recurrence and limited clinical benefit. The recent addition of cyclin-dependent kinase 4 (CDK4) and CDK6 inhibitors (palbociclib, ribociclib, abemaciclib) to ET have remarkably improved the outcome of patients with HR+ advanced breast cancer (ABC) compared with anti-estrogens alone, by targeting the cell-cycle machinery and overcoming some aspects of endocrine resistance. However, egies to enhance their efficacy in improving survival and quality of life of patients affected whichHR+, HER2−,patients areABC.the better candidates for these drugs, which are the main characteristics for a better selection of patients or if there are predictive biomarkers of response, is still unknown. In this review we reported the mechanism of action of CDK4/6 inhibitors as well as their potential mechanism Keywords: CDK4/6 inhibitors; breast cancer; endocrine therapy (ET); advanced breast cancer (Aof resistance, their implications in clinical practice and the forthcoming strategies to enhance their endocrine resistance efficacy in improving survival and quality of life of patients affected with HR+, HER2−, ABC.
Lingua originaleEnglish
pagine (da-a)1-20
Numero di pagine20
RivistaCancers
Volume13
DOI
Stato di pubblicazionePubblicato - 2021

Keywords

  • Advanced breast cancer (ABC)
  • Breast cancer
  • CDK4/6 inhibitors
  • Endocrine resistance 1. Introduction
  • Endocrine therapy (ET)

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