Abstract
CD26 is a widely expressed transmembrane glycoprotein with peptidase activity in its extracellular domain and which regulates multiple biological processes. It acts mainly as catabolic enzyme for a number of circulating proteins involved in common pathological conditions such as diabetes and cardiovascular disease and may represent a target to modulate bioavailability of crucial substrates. The aim of the present review is to summarize data regarding CD26-based pharmacological interventions. Four main subtopics were identified:1) CD26 as the target of pharmacological inhibitors to increase bioavailability of glucagon-like petide-1 (GLP-1) and hence to enhance GLP-1 glucose-lowering activity in diabetic patients; 2) role of CD26 in the physiology and pathology of the cardiovascular system; 3) the adverse prognostic value of CD26 expression on cancer cells; 4) CD26 down-regulation on lymphocytes as a mechanism of TGF-beta immunomodulation.
Lingua originale | English |
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pagine (da-a) | 157-164 |
Numero di pagine | 8 |
Rivista | Current Clinical Pharmacology |
Volume | 9 |
DOI | |
Stato di pubblicazione | Pubblicato - 2014 |
Keywords
- Animals
- Cardiovascular Diseases
- Diabetes Mellitus
- Dipeptidyl Peptidase 4
- Dipeptidyl-Peptidase IV Inhibitors
- Glucagon-Like Peptide 1
- Humans
- Molecular Targeted Therapy
- Neoplasms