CD200 and prognosis in chronic lymphocytic leukemia: Conflicting results

Luca Laurenti, Celeste Vitale, Silvia Bellesi, Giovanni D'Arena, Luciana Valvano, Teodora Statuto, Daniela Lamorte, Pellegrino Musto, Fiorella D'Auria

Risultato della ricerca: Contributo in rivistaArticolo in rivista

4 Citazioni (Scopus)

Abstract

CD200 is a transmembrane type Ia glycoprotein belonging to theimmunoglobulin superfamily [1].It isexpressed byvariouscell types,such as B cells, a subset of T cells including activated T cells, thymo-cytes, endothelial cells, and neurons. CD200 surface expression hasbeenshowntohavearelevantroleinthedifferentialdiagnosisofB-cellchronic lymphoproliferative disorders (B-CLPDs) [2]. The major con-tributionofCD200istheabilitytodiscriminatebetweenchroniclym-phocytic leukemia (CLL) and mantle cell lymphoma (MCL), and be-tweenhairycellleukemiaanditsvariantform[3].Furthermore,ithasbeenalsodemonstratedaroleofCD200inthedifferentialdiagnosisofother forms of B-CLPDs, when incorporated in panels including othersurface markers [4,5]. However, little is known about the prognosticsignificanceofCD200expressioninCLL
Lingua originaleEnglish
pagine (da-a)106169-N/A
RivistaLeukemia Research
Volume83
DOI
Stato di pubblicazionePubblicato - 2019

Keywords

  • CLL

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