CD200 and prognosis in chronic lymphocytic leukemia: Conflicting results

Giovanni D'Arena; Luciana Valvano; Celeste Vitale; Marta Coscia; Teodora Statuto; Silvia Bellesi; Daniela Lamorte; Pellegrino Musto; Luca Laurenti; Fiorella D'Auria

doi:10.1016/j.leukres.2019.106169

CD200 and prognosis in chronic lymphocytic leukemia: Conflicting results

Giovanni D'Arena, Luciana Valvano, Celeste Vitale, Marta Coscia, Teodora Statuto, Silvia Bellesi, Daniela Lamorte, Pellegrino Musto, Luca Laurenti, Fiorella D'Auria

IRCCS Centro di riferimento oncologico della Basilicata - Rionero in Vulture (PZ)

Risultato della ricerca: Contributo in rivista › Articolo in rivista

4 Citazioni (Scopus)

Abstract

CD200 is a transmembrane type Ia glycoprotein belonging to theimmunoglobulin superfamily [1].It isexpressed byvariouscell types,such as B cells, a subset of T cells including activated T cells, thymo-cytes, endothelial cells, and neurons. CD200 surface expression hasbeenshowntohavearelevantroleinthedifferentialdiagnosisofB-cellchronic lymphoproliferative disorders (B-CLPDs) [2]. The major con-tributionofCD200istheabilitytodiscriminatebetweenchroniclym-phocytic leukemia (CLL) and mantle cell lymphoma (MCL), and be-tweenhairycellleukemiaanditsvariantform[3].Furthermore,ithasbeenalsodemonstratedaroleofCD200inthedifferentialdiagnosisofother forms of B-CLPDs, when incorporated in panels including othersurface markers [4,5]. However, little is known about the prognosticsignificanceofCD200expressioninCLL

Lingua originale	English
pagine (da-a)	106169-N/A
Rivista	Leukemia Research
Volume	83
DOI	https://doi.org/10.1016/j.leukres.2019.106169
Stato di pubblicazione	Pubblicato - 2019

Keywords

CLL

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10.1016/j.leukres.2019.106169

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title = "CD200 and prognosis in chronic lymphocytic leukemia: Conflicting results",

abstract = "CD200 is a transmembrane type Ia glycoprotein belonging to theimmunoglobulin superfamily [1].It isexpressed byvariouscell types,such as B cells, a subset of T cells including activated T cells, thymo-cytes, endothelial cells, and neurons. CD200 surface expression hasbeenshowntohavearelevantroleinthedifferentialdiagnosisofB-cellchronic lymphoproliferative disorders (B-CLPDs) [2]. The major con-tributionofCD200istheabilitytodiscriminatebetweenchroniclym-phocytic leukemia (CLL) and mantle cell lymphoma (MCL), and be-tweenhairycellleukemiaanditsvariantform[3].Furthermore,ithasbeenalsodemonstratedaroleofCD200inthedifferentialdiagnosisofother forms of B-CLPDs, when incorporated in panels including othersurface markers [4,5]. However, little is known about the prognosticsignificanceofCD200expressioninCLL",

keywords = "CLL, CLL",

author = "Giovanni D'Arena and Luciana Valvano and Celeste Vitale and Marta Coscia and Teodora Statuto and Silvia Bellesi and Daniela Lamorte and Pellegrino Musto and Luca Laurenti and Fiorella D'Auria",

year = "2019",

doi = "10.1016/j.leukres.2019.106169",

language = "English",

volume = "83",

pages = "106169--N/A",

journal = "Leukemia Research",

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T1 - CD200 and prognosis in chronic lymphocytic leukemia: Conflicting results

AU - D'Arena, Giovanni

AU - Valvano, Luciana

AU - Vitale, Celeste

AU - Coscia, Marta

AU - Statuto, Teodora

AU - Bellesi, Silvia

AU - Lamorte, Daniela

AU - Musto, Pellegrino

AU - Laurenti, Luca

AU - D'Auria, Fiorella

PY - 2019

Y1 - 2019

N2 - CD200 is a transmembrane type Ia glycoprotein belonging to theimmunoglobulin superfamily [1].It isexpressed byvariouscell types,such as B cells, a subset of T cells including activated T cells, thymo-cytes, endothelial cells, and neurons. CD200 surface expression hasbeenshowntohavearelevantroleinthedifferentialdiagnosisofB-cellchronic lymphoproliferative disorders (B-CLPDs) [2]. The major con-tributionofCD200istheabilitytodiscriminatebetweenchroniclym-phocytic leukemia (CLL) and mantle cell lymphoma (MCL), and be-tweenhairycellleukemiaanditsvariantform[3].Furthermore,ithasbeenalsodemonstratedaroleofCD200inthedifferentialdiagnosisofother forms of B-CLPDs, when incorporated in panels including othersurface markers [4,5]. However, little is known about the prognosticsignificanceofCD200expressioninCLL

AB - CD200 is a transmembrane type Ia glycoprotein belonging to theimmunoglobulin superfamily [1].It isexpressed byvariouscell types,such as B cells, a subset of T cells including activated T cells, thymo-cytes, endothelial cells, and neurons. CD200 surface expression hasbeenshowntohavearelevantroleinthedifferentialdiagnosisofB-cellchronic lymphoproliferative disorders (B-CLPDs) [2]. The major con-tributionofCD200istheabilitytodiscriminatebetweenchroniclym-phocytic leukemia (CLL) and mantle cell lymphoma (MCL), and be-tweenhairycellleukemiaanditsvariantform[3].Furthermore,ithasbeenalsodemonstratedaroleofCD200inthedifferentialdiagnosisofother forms of B-CLPDs, when incorporated in panels including othersurface markers [4,5]. However, little is known about the prognosticsignificanceofCD200expressioninCLL

KW - CLL

UR - http://hdl.handle.net/10807/142506

UR - http://www.elsevier.com/locate/leukres

U2 - 10.1016/j.leukres.2019.106169

DO - 10.1016/j.leukres.2019.106169

M3 - Article

SN - 0145-2126

VL - 83

SP - 106169-N/A

JO - Leukemia Research

JF - Leukemia Research

ER -

CD200 and prognosis in chronic lymphocytic leukemia: Conflicting results

Abstract

Keywords

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