TY - JOUR
T1 - Case Report: Trichosporon japonicum Fungemia in a Pediatric Patient With Refractory Acute B Cell Lymphoblastic Leukemia
AU - Albitar-Nehme, S.
AU - Agosta, M.
AU - Kowalska, A. H.
AU - Mancinelli, L.
AU - Onori, M.
AU - Lucignano, B.
AU - Mattana, G.
AU - Quagliarella, F.
AU - Cefalo, M. G.
AU - Merli, P.
AU - Locatelli, Franco
AU - Perno, C. F.
AU - Bernaschi, P.
PY - 2022
Y1 - 2022
N2 - Trichosporon japonicum is a very rare opportunistic yeast causing fungal disease in humans, especially in immunocompromised hosts. Here, we describe a new case of T. japonicum isolated from the blood of a pyrexial pediatric patient with refractory acute B cell lymphoblastic leukemia and acute respiratory distress. Prompt diagnosis through early clinical suspicion and appropriate molecular microbiology analysis allowed the yeast to be accurately identified at species level. Subsequent drug susceptibility testing and focused antifungal treatment with voriconazole and amphotericin B led to a complete clinical and mycological resolution of the infection, which represents the second successful case of T. japonicum bloodstream infection described in literature to date.
AB - Trichosporon japonicum is a very rare opportunistic yeast causing fungal disease in humans, especially in immunocompromised hosts. Here, we describe a new case of T. japonicum isolated from the blood of a pyrexial pediatric patient with refractory acute B cell lymphoblastic leukemia and acute respiratory distress. Prompt diagnosis through early clinical suspicion and appropriate molecular microbiology analysis allowed the yeast to be accurately identified at species level. Subsequent drug susceptibility testing and focused antifungal treatment with voriconazole and amphotericin B led to a complete clinical and mycological resolution of the infection, which represents the second successful case of T. japonicum bloodstream infection described in literature to date.
KW - MALDI-TOF MS biotyper
KW - Trichosporon japonicum
KW - acute B cell lymphoblastic leukemia
KW - amphotericin B
KW - voriconazole
KW - MALDI-TOF MS biotyper
KW - Trichosporon japonicum
KW - acute B cell lymphoblastic leukemia
KW - amphotericin B
KW - voriconazole
UR - https://publicatt.unicatt.it/handle/10807/228995
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85127125932&origin=inward
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85127125932&origin=inward
U2 - 10.3389/fped.2022.861476
DO - 10.3389/fped.2022.861476
M3 - Article
SN - 2296-2360
VL - 10
SP - 1
EP - 4
JO - Frontiers in Pediatrics
JF - Frontiers in Pediatrics
IS - 10
ER -