Case Report: Precision COVID-19 Immunization Strategy to Overcome Individual Fragility: A Case of Generalized Lipodystrophy Type 4

Salvatore Zaffina; Eva Piano Mortari; Reparata Rosa Di Prinzio; Marco Cappa; Antonio Novelli; Emanuele Agolini; Massimiliano Raponi; Bruno Dallapiccola; Franco Locatelli; Carlo Federico Perno; Rita Carsetti

doi:10.3389/fimmu.2022.869042

Case Report: Precision COVID-19 Immunization Strategy to Overcome Individual Fragility: A Case of Generalized Lipodystrophy Type 4

Salvatore Zaffina, Eva Piano Mortari, Reparata Rosa Di Prinzio, Marco Cappa, Antonio Novelli, Emanuele Agolini, Massimiliano Raponi, Bruno Dallapiccola, Franco Locatelli, Carlo Federico Perno, Rita Carsetti

IRCCS Ospedale pediatrico Bambino Gesù - Roma

Risultato della ricerca: Contributo in rivista › Articolo in rivista

Abstract

A 48-year-old patient affected with congenital generalized lipodystrophy type 4 failed to respond to two doses of the BNT162b2 vaccine, consisting of lipid nanoparticle encapsulated mRNA. As the disease is caused by biallelic variants of CAVIN1, a molecule indispensable for lipid endocytosis and regulation, we complemented the vaccination cycle with a single dose of the Ad26.COV2 vaccine. Adenovirus-based vaccine entry is mediated by the interaction with adenovirus receptors and transport occurs in clathrin-coated pits. Ten days after Ad26.COV2 administration, S- and RBD-specific antibodies and high-affinity memory B cells increased significantly to values close to those observed in Health Care Worker controls.

Lingua originale	English
pagine (da-a)	1-6
Numero di pagine	6
Rivista	Frontiers in Immunology
Volume	13
DOI	https://doi.org/10.3389/fimmu.2022.869042
Stato di pubblicazione	Pubblicato - 2022

Keywords

case report
CAVIN1
SARS-CoV-2 vaccine
memory B cells
congenital generalized lipodystrophy type 4

OSS delle Nazioni Unite

Questo processo contribuisce al raggiungimento dei seguenti obiettivi di sviluppo sostenibile

Accesso al documento

10.3389/fimmu.2022.869042

Altri file e collegamenti

Link a IRIS PubliCatt

Cita questo

Zaffina, S., Piano Mortari, E., Di Prinzio, R. R., Cappa, M., Novelli, A., Agolini, E., Raponi, M., Dallapiccola, B., Locatelli, F., Perno, C. F., & Carsetti, R. (2022). Case Report: Precision COVID-19 Immunization Strategy to Overcome Individual Fragility: A Case of Generalized Lipodystrophy Type 4. Frontiers in Immunology, 13, 1-6. https://doi.org/10.3389/fimmu.2022.869042

@article{ee10b5a8cad94556a7bb56ef0adeb50f,

title = "Case Report: Precision COVID-19 Immunization Strategy to Overcome Individual Fragility: A Case of Generalized Lipodystrophy Type 4",

abstract = "A 48-year-old patient affected with congenital generalized lipodystrophy type 4 failed to respond to two doses of the BNT162b2 vaccine, consisting of lipid nanoparticle encapsulated mRNA. As the disease is caused by biallelic variants of CAVIN1, a molecule indispensable for lipid endocytosis and regulation, we complemented the vaccination cycle with a single dose of the Ad26.COV2 vaccine. Adenovirus-based vaccine entry is mediated by the interaction with adenovirus receptors and transport occurs in clathrin-coated pits. Ten days after Ad26.COV2 administration, S- and RBD-specific antibodies and high-affinity memory B cells increased significantly to values close to those observed in Health Care Worker controls.",

keywords = "case report, CAVIN1, SARS-CoV-2 vaccine, memory B cells, congenital generalized lipodystrophy type 4, case report, CAVIN1, SARS-CoV-2 vaccine, memory B cells, congenital generalized lipodystrophy type 4",

author = "Salvatore Zaffina and {Piano Mortari}, Eva and {Di Prinzio}, {Reparata Rosa} and Marco Cappa and Antonio Novelli and Emanuele Agolini and Massimiliano Raponi and Bruno Dallapiccola and Franco Locatelli and Perno, {Carlo Federico} and Rita Carsetti",

year = "2022",

doi = "10.3389/fimmu.2022.869042",

language = "English",

volume = "13",

pages = "1--6",

journal = "Frontiers in Immunology",

issn = "1664-3224",

publisher = "Frontiers Media SA",

}

Zaffina, S, Piano Mortari, E, Di Prinzio, RR, Cappa, M, Novelli, A, Agolini, E, Raponi, M, Dallapiccola, B, Locatelli, F, Perno, CF & Carsetti, R 2022, 'Case Report: Precision COVID-19 Immunization Strategy to Overcome Individual Fragility: A Case of Generalized Lipodystrophy Type 4', Frontiers in Immunology, vol. 13, pagg. 1-6. https://doi.org/10.3389/fimmu.2022.869042

TY - JOUR

T1 - Case Report: Precision COVID-19 Immunization Strategy to Overcome Individual Fragility: A Case of Generalized Lipodystrophy Type 4

AU - Zaffina, Salvatore

AU - Piano Mortari, Eva

AU - Di Prinzio, Reparata Rosa

AU - Cappa, Marco

AU - Novelli, Antonio

AU - Agolini, Emanuele

AU - Raponi, Massimiliano

AU - Dallapiccola, Bruno

AU - Locatelli, Franco

AU - Perno, Carlo Federico

AU - Carsetti, Rita

PY - 2022

Y1 - 2022

N2 - A 48-year-old patient affected with congenital generalized lipodystrophy type 4 failed to respond to two doses of the BNT162b2 vaccine, consisting of lipid nanoparticle encapsulated mRNA. As the disease is caused by biallelic variants of CAVIN1, a molecule indispensable for lipid endocytosis and regulation, we complemented the vaccination cycle with a single dose of the Ad26.COV2 vaccine. Adenovirus-based vaccine entry is mediated by the interaction with adenovirus receptors and transport occurs in clathrin-coated pits. Ten days after Ad26.COV2 administration, S- and RBD-specific antibodies and high-affinity memory B cells increased significantly to values close to those observed in Health Care Worker controls.

AB - A 48-year-old patient affected with congenital generalized lipodystrophy type 4 failed to respond to two doses of the BNT162b2 vaccine, consisting of lipid nanoparticle encapsulated mRNA. As the disease is caused by biallelic variants of CAVIN1, a molecule indispensable for lipid endocytosis and regulation, we complemented the vaccination cycle with a single dose of the Ad26.COV2 vaccine. Adenovirus-based vaccine entry is mediated by the interaction with adenovirus receptors and transport occurs in clathrin-coated pits. Ten days after Ad26.COV2 administration, S- and RBD-specific antibodies and high-affinity memory B cells increased significantly to values close to those observed in Health Care Worker controls.

KW - case report

KW - CAVIN1

KW - SARS-CoV-2 vaccine

KW - memory B cells

KW - congenital generalized lipodystrophy type 4

KW - case report

KW - CAVIN1

KW - SARS-CoV-2 vaccine

KW - memory B cells

KW - congenital generalized lipodystrophy type 4

UR - http://hdl.handle.net/10807/229770

U2 - 10.3389/fimmu.2022.869042

DO - 10.3389/fimmu.2022.869042

M3 - Article

SN - 1664-3224

VL - 13

SP - 1

EP - 6

JO - Frontiers in Immunology

JF - Frontiers in Immunology

ER -

Case Report: Precision COVID-19 Immunization Strategy to Overcome Individual Fragility: A Case of Generalized Lipodystrophy Type 4

Abstract

Keywords

OSS delle Nazioni Unite

Accesso al documento

Altri file e collegamenti

Fingerprint

Cita questo