Cartilage differentiation in ependymoma: histogenetic considerations on a new case

Antonella Coli, Mariangela Novello, Luca Massimi, Massimo Caldarelli, Valentina Ranucci, Libero Lauriola

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

2 Citazioni (Scopus)


The presence of cartilage in gliomas is a very unusual finding and has been mainly reported in ependymomas and in astrocytomas. A derivation of cartilage from neuroepithelial cells through a neuroepithelial-mesenchymal transition or directly from blood vessel-associated multipotent stromal elements has been proposed. We herein describe a further case of ependymoma with the presence of cartilage in a child affected by a tumor in the posterior fossa. In this case, only the last recurrence, characterized by focal areas of anaplasia, contained a nodule of cartilage. The immunohistochemical expression of fibronectin, tenascin-C, and CD44 was investigated, and the possible role of these molecules in the process of cartilage formation is discussed. Moreover, the literature on the subject is reviewed.
Lingua originaleEnglish
pagine (da-a)1301-1305
Numero di pagine5
Stato di pubblicazionePubblicato - 2014


  • Cartilage
  • Ependymoma
  • Extracellular matrix
  • Glial tumors
  • Tenascin-C


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