TY - JOUR
T1 - Carotenoid intake and head and neck cancer: a pooled analysis in the International Head and Neck Cancer Epidemiology Consortium.
AU - Leoncini, Emanuele
AU - Edefonti, Valeria
AU - Hashibe, Mia
AU - Parpinel, Maria
AU - Cadoni, Gabriella
AU - Ferraroni, Monica
AU - Serraino, Diego
AU - Matsuo, Keitaro
AU - Olshan, Andrew F.
AU - Zevallos, Jose P.
AU - Winn, Deborah M.
AU - Moysich, Kirsten
AU - Zhang, Zuo-Feng
AU - Morgenstern, Hal
AU - Levi, Fabio
AU - Kelsey, Karl
AU - Mcclean, Michael
AU - Bosetti, Cristina
AU - Schantz, Stimson
AU - Yu, Guo-Pei
AU - Boffetta, Paolo
AU - Lee, Yuan-Chin Amy
AU - Chuang, Shu-Chun
AU - Decarli, Adriano
AU - La Vecchia, Carlo
AU - Boccia, Stefania
PY - 2016
Y1 - 2016
N2 - Food and nutrition play an important role in head and neck cancer (HNC) etiology; however, the role of carotenoids remains largely undefined. We explored the relation of HNC risk with the intake of carotenoids within the International Head and Neck Cancer Epidemiology Consortium. We pooled individual-level data from 10 case-control studies conducted in Europe, North America, and Japan. The analysis included 18,207 subjects (4414 with oral and pharyngeal cancer, 1545 with laryngeal cancer, and 12,248 controls), categorized by quintiles of carotenoid intake from natural sources. Comparing the highest with the lowest quintile, the risk reduction associated with total carotenoid intake was 39 % (95 % CI 29-47 %) for oral/pharyngeal cancer and 39 % (95 % CI 24-50 %) for laryngeal cancer. Intakes of β-carotene equivalents, β-cryptoxanthin, lycopene, and lutein plus zeaxanthin were associated with at least 18 % reduction in the rate of oral and pharyngeal cancer (95 % CI 6-29 %) and 17 % reduction in the rate of laryngeal cancer (95 % CI 0-32 %). The overall protective effect of carotenoids on HNC was stronger for subjects reporting greater alcohol consumption (p < 0.05). The odds ratio for the combined effect of low carotenoid intake and high alcohol or tobacco consumption versus high carotenoid intake and low alcohol or tobacco consumption ranged from 7 (95 % CI 5-9) to 33 (95 % CI 23-49). A diet rich in carotenoids may protect against HNC. Persons with both low carotenoid intake and high tobacco or alcohol are at substantially higher risk of HNC.
AB - Food and nutrition play an important role in head and neck cancer (HNC) etiology; however, the role of carotenoids remains largely undefined. We explored the relation of HNC risk with the intake of carotenoids within the International Head and Neck Cancer Epidemiology Consortium. We pooled individual-level data from 10 case-control studies conducted in Europe, North America, and Japan. The analysis included 18,207 subjects (4414 with oral and pharyngeal cancer, 1545 with laryngeal cancer, and 12,248 controls), categorized by quintiles of carotenoid intake from natural sources. Comparing the highest with the lowest quintile, the risk reduction associated with total carotenoid intake was 39 % (95 % CI 29-47 %) for oral/pharyngeal cancer and 39 % (95 % CI 24-50 %) for laryngeal cancer. Intakes of β-carotene equivalents, β-cryptoxanthin, lycopene, and lutein plus zeaxanthin were associated with at least 18 % reduction in the rate of oral and pharyngeal cancer (95 % CI 6-29 %) and 17 % reduction in the rate of laryngeal cancer (95 % CI 0-32 %). The overall protective effect of carotenoids on HNC was stronger for subjects reporting greater alcohol consumption (p < 0.05). The odds ratio for the combined effect of low carotenoid intake and high alcohol or tobacco consumption versus high carotenoid intake and low alcohol or tobacco consumption ranged from 7 (95 % CI 5-9) to 33 (95 % CI 23-49). A diet rich in carotenoids may protect against HNC. Persons with both low carotenoid intake and high tobacco or alcohol are at substantially higher risk of HNC.
KW - head and neck cancer
KW - head and neck cancer
UR - http://hdl.handle.net/10807/92971
U2 - 10.1007/s10654-015-0036-3
DO - 10.1007/s10654-015-0036-3
M3 - Article
SN - 0393-2990
VL - 2016
SP - 369
EP - 383
JO - European Journal of Epidemiology
JF - European Journal of Epidemiology
ER -