Cardiovascular responses to the isoprostanes iPF(2alpha)-III and iPE(2)-III are mediated via the thromboxane A(2) receptor in vivo

Bianca Rocca, Lp Audoly, Je Fabre, Bh Koller, D Thomas, Al Loeb, Tm Coffman, Ga Fitzgerald

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Isoprostanes (iPs) are free radical-catalyzed products of arachidonic acid that reflect lipid peroxidation in vivo. Several iPs exert biological effects in vitro and may contribute to the functional consequences of oxidant stress. For example, iPF(2alpha)-III (8-iso PGF(2alpha)) and iPE(2)-III modulate platelet function and vascular tone. Although these effects are blocked by antagonists of the receptor (TP) for the cyclooxygenase product thromboxane A(2), it has been speculated that the iPs may activate a receptor related to, but distinct from, the TP.
Lingua originaleEnglish
pagine (da-a)2833-2840
Numero di pagine8
RivistaCirculation
Volume101
Stato di pubblicazionePubblicato - 2000

Keywords

  • Angiotensin II
  • Animals
  • Blood Platelets
  • Blood Pressure
  • Cardiovascular System
  • Dinoprost
  • Mice
  • Mice, Transgenic
  • Platelet Aggregation
  • Protein Isoforms
  • Receptors, Thromboxane
  • Reference Values

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