Cardiovascular disease and SARS-CoV-2: The role of host immune response versus direct viral injury

Piergiorgio Bruno; Andrea Flex; Federico Biscetti; Elisabetta Nardella; Andrea Leonardo Cecchini; Raffaele Landolfi; M. M. Rando

doi:10.3390/ijms21218141

Cardiovascular disease and SARS-CoV-2: The role of host immune response versus direct viral injury

Piergiorgio Bruno, Andrea Flex, Federico Biscetti, Elisabetta Nardella, Andrea Leonardo Cecchini, Raffaele Landolfi, M. M. Rando

Risultato della ricerca: Contributo in rivista › Articolo in rivista

1 Citazioni (Scopus)

Abstract

The 2019 novel coronavirus [2019-nCoV], which started to spread from December 2019 onwards, caused a global pandemic. Besides being responsible for the severe acute respiratory syndrome 2 [SARS-CoV-2], the virus can affect other organs causing various symptoms. A close relationship between SARS-CoV-2 and the cardiovascular system has been shown, demonstrating an epidemiological linkage between SARS-CoV-2 and cardiac injury. There are emerging data regarding possible direct myocardial damage by 2019-nCoV. In this review, the most important available evidences will be discussed to clarify the precise mechanisms of cardiovascular injury in SARS-CoV-2 patients, even if further researches are needed.

Lingua originale	English
pagine (da-a)	1-14
Numero di pagine	14
Rivista	International Journal of Molecular Sciences
Volume	21
DOI	https://doi.org/10.3390/ijms21218141
Stato di pubblicazione	Pubblicato - 2020

Keywords

Cardiovascular diseases
SARS-CoV-2
Animals
Betacoronavirus
COVID-19
Coronavirus Infections
Humans
Pandemics
Pneumonia, Viral
Cardiovascular Diseases

Accesso al documento

10.3390/ijms21218141

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title = "Cardiovascular disease and SARS-CoV-2: The role of host immune response versus direct viral injury",

abstract = "The 2019 novel coronavirus [2019-nCoV], which started to spread from December 2019 onwards, caused a global pandemic. Besides being responsible for the severe acute respiratory syndrome 2 [SARS-CoV-2], the virus can affect other organs causing various symptoms. A close relationship between SARS-CoV-2 and the cardiovascular system has been shown, demonstrating an epidemiological linkage between SARS-CoV-2 and cardiac injury. There are emerging data regarding possible direct myocardial damage by 2019-nCoV. In this review, the most important available evidences will be discussed to clarify the precise mechanisms of cardiovascular injury in SARS-CoV-2 patients, even if further researches are needed.",

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Cardiovascular disease and SARS-CoV-2: The role of host immune response versus direct viral injury. / Bruno, Piergiorgio ; Flex, Andrea; Biscetti, Federico; Nardella, Elisabetta; Cecchini, Andrea Leonardo; Landolfi, Raffaele; Rando, M. M.

In: International Journal of Molecular Sciences, Vol. 21, 2020, pag. 1-14.

Risultato della ricerca: Contributo in rivista › Articolo in rivista

TY - JOUR

T1 - Cardiovascular disease and SARS-CoV-2: The role of host immune response versus direct viral injury

AU - Bruno, Piergiorgio

AU - Flex, Andrea

AU - Biscetti, Federico

AU - Nardella, Elisabetta

AU - Cecchini, Andrea Leonardo

AU - Landolfi, Raffaele

AU - Rando, M. M.

PY - 2020

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AB - The 2019 novel coronavirus [2019-nCoV], which started to spread from December 2019 onwards, caused a global pandemic. Besides being responsible for the severe acute respiratory syndrome 2 [SARS-CoV-2], the virus can affect other organs causing various symptoms. A close relationship between SARS-CoV-2 and the cardiovascular system has been shown, demonstrating an epidemiological linkage between SARS-CoV-2 and cardiac injury. There are emerging data regarding possible direct myocardial damage by 2019-nCoV. In this review, the most important available evidences will be discussed to clarify the precise mechanisms of cardiovascular injury in SARS-CoV-2 patients, even if further researches are needed.

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KW - Cardiovascular diseases

KW - SARS-CoV-2

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KW - Betacoronavirus

KW - COVID-19

KW - Coronavirus Infections

KW - Humans

KW - Pandemics

KW - Pneumonia, Viral

KW - Cardiovascular Diseases

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