Cardiovascular disease and SARS-CoV-2: The role of host immune response versus direct viral injury

Federico Biscetti; M. M. Rando; Elisabetta Nardella; Andrea Leonardo Cecchini; Piergiorgio Bruno; Raffaele Landolfi; Andrea Flex

doi:10.3390/ijms21218141

Cardiovascular disease and SARS-CoV-2: The role of host immune response versus direct viral injury

Federico Biscetti, M. M. Rando, Elisabetta Nardella, Andrea Leonardo Cecchini, Piergiorgio Bruno, Raffaele Landolfi, Andrea Flex

Risultato della ricerca: Contributo in rivista › Articolo in rivista

1 Citazioni (Scopus)

Abstract

The 2019 novel coronavirus [2019-nCoV], which started to spread from December 2019 onwards, caused a global pandemic. Besides being responsible for the severe acute respiratory syndrome 2 [SARS-CoV-2], the virus can affect other organs causing various symptoms. A close relationship between SARS-CoV-2 and the cardiovascular system has been shown, demonstrating an epidemiological linkage between SARS-CoV-2 and cardiac injury. There are emerging data regarding possible direct myocardial damage by 2019-nCoV. In this review, the most important available evidences will be discussed to clarify the precise mechanisms of cardiovascular injury in SARS-CoV-2 patients, even if further researches are needed.

Lingua originale	English
pagine (da-a)	1-14
Numero di pagine	14
Rivista	International Journal of Molecular Sciences
Volume	21
DOI	https://doi.org/10.3390/ijms21218141
Stato di pubblicazione	Pubblicato - 2020

Keywords

Animals
Betacoronavirus
COVID-19
Cardiovascular Diseases
Cardiovascular diseases
Coronavirus Infections
Humans
Pandemics
Pneumonia, Viral
SARS-CoV-2

OSS delle Nazioni Unite

Questo processo contribuisce al raggiungimento dei seguenti obiettivi di sviluppo sostenibile

Accesso al documento

10.3390/ijms21218141

Altri file e collegamenti

Link a IRIS PubliCatt

Cita questo

@article{90c552ccf29c47ecb0055fe5cafefd0c,

title = "Cardiovascular disease and SARS-CoV-2: The role of host immune response versus direct viral injury",

abstract = "The 2019 novel coronavirus [2019-nCoV], which started to spread from December 2019 onwards, caused a global pandemic. Besides being responsible for the severe acute respiratory syndrome 2 [SARS-CoV-2], the virus can affect other organs causing various symptoms. A close relationship between SARS-CoV-2 and the cardiovascular system has been shown, demonstrating an epidemiological linkage between SARS-CoV-2 and cardiac injury. There are emerging data regarding possible direct myocardial damage by 2019-nCoV. In this review, the most important available evidences will be discussed to clarify the precise mechanisms of cardiovascular injury in SARS-CoV-2 patients, even if further researches are needed.",

keywords = "Animals, Betacoronavirus, COVID-19, Cardiovascular Diseases, Cardiovascular diseases, Coronavirus Infections, Humans, Pandemics, Pneumonia, Viral, SARS-CoV-2, Animals, Betacoronavirus, COVID-19, Cardiovascular Diseases, Cardiovascular diseases, Coronavirus Infections, Humans, Pandemics, Pneumonia, Viral, SARS-CoV-2",

author = "Federico Biscetti and Rando, {M. M.} and Elisabetta Nardella and Cecchini, {Andrea Leonardo} and Piergiorgio Bruno and Raffaele Landolfi and Andrea Flex",

year = "2020",

doi = "10.3390/ijms21218141",

language = "English",

volume = "21",

pages = "1--14",

journal = "International Journal of Molecular Sciences",

issn = "1661-6596",

publisher = "Basel (Matthaeustrasse 11) : Molecular Diversity Preservation International MDPI, cop. 2005-",

}

TY - JOUR

T1 - Cardiovascular disease and SARS-CoV-2: The role of host immune response versus direct viral injury

AU - Biscetti, Federico

AU - Rando, M. M.

AU - Nardella, Elisabetta

AU - Cecchini, Andrea Leonardo

AU - Bruno, Piergiorgio

AU - Landolfi, Raffaele

AU - Flex, Andrea

PY - 2020

Y1 - 2020

N2 - The 2019 novel coronavirus [2019-nCoV], which started to spread from December 2019 onwards, caused a global pandemic. Besides being responsible for the severe acute respiratory syndrome 2 [SARS-CoV-2], the virus can affect other organs causing various symptoms. A close relationship between SARS-CoV-2 and the cardiovascular system has been shown, demonstrating an epidemiological linkage between SARS-CoV-2 and cardiac injury. There are emerging data regarding possible direct myocardial damage by 2019-nCoV. In this review, the most important available evidences will be discussed to clarify the precise mechanisms of cardiovascular injury in SARS-CoV-2 patients, even if further researches are needed.

AB - The 2019 novel coronavirus [2019-nCoV], which started to spread from December 2019 onwards, caused a global pandemic. Besides being responsible for the severe acute respiratory syndrome 2 [SARS-CoV-2], the virus can affect other organs causing various symptoms. A close relationship between SARS-CoV-2 and the cardiovascular system has been shown, demonstrating an epidemiological linkage between SARS-CoV-2 and cardiac injury. There are emerging data regarding possible direct myocardial damage by 2019-nCoV. In this review, the most important available evidences will be discussed to clarify the precise mechanisms of cardiovascular injury in SARS-CoV-2 patients, even if further researches are needed.

KW - Animals

KW - Betacoronavirus

KW - COVID-19

KW - Cardiovascular Diseases

KW - Cardiovascular diseases

KW - Coronavirus Infections

KW - Humans

KW - Pandemics

KW - Pneumonia, Viral

KW - SARS-CoV-2

KW - Animals

KW - Betacoronavirus

KW - COVID-19

KW - Cardiovascular Diseases

KW - Cardiovascular diseases

KW - Coronavirus Infections

KW - Humans

KW - Pandemics

KW - Pneumonia, Viral

KW - SARS-CoV-2

UR - http://hdl.handle.net/10807/177893

U2 - 10.3390/ijms21218141

DO - 10.3390/ijms21218141

M3 - Article

SN - 1661-6596

VL - 21

SP - 1

EP - 14

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

ER -

Cardiovascular disease and SARS-CoV-2: The role of host immune response versus direct viral injury

Abstract

Keywords

OSS delle Nazioni Unite

Accesso al documento

Altri file e collegamenti

Fingerprint

Cita questo