Cardiovascular disease and SARS-CoV-2: The role of host immune response versus direct viral injury

Federico Biscetti; M. M. Rando; E. Nardella; A. L. Cecchini; P. Bruno; R. Landolfi; Andrea Flex

doi:10.3390/ijms21218141

Cardiovascular disease and SARS-CoV-2: The role of host immune response versus direct viral injury

Federico Biscetti^*, M. M. Rando, E. Nardella, A. L. Cecchini, P. Bruno, R. Landolfi, Andrea Flex

^*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivista › Articolo

1 Citazioni (Scopus)

Abstract

The 2019 novel coronavirus [2019-nCoV], which started to spread from December 2019 onwards, caused a global pandemic. Besides being responsible for the severe acute respiratory syndrome 2 [SARS-CoV-2], the virus can affect other organs causing various symptoms. A close relationship between SARS-CoV-2 and the cardiovascular system has been shown, demonstrating an epidemiological linkage between SARS-CoV-2 and cardiac injury. There are emerging data regarding possible direct myocardial damage by 2019-nCoV. In this review, the most important available evidences will be discussed to clarify the precise mechanisms of cardiovascular injury in SARS-CoV-2 patients, even if further researches are needed.

Lingua originale	Inglese
pagine (da-a)	1-14
Numero di pagine	14
Rivista	International Journal of Molecular Sciences
Volume	21
Numero di pubblicazione	21
DOI	https://doi.org/10.3390/ijms21218141
Stato di pubblicazione	Pubblicato - 2020

All Science Journal Classification (ASJC) codes

Catalisi
Biologia Molecolare
Spettroscopia
Informatica Applicata
Chimica Fisica e Teorica
Chimica Organica
Chimica Inorganica

Keywords

Animals
Betacoronavirus
COVID-19
Cardiovascular Diseases
Cardiovascular diseases
Coronavirus Infections
Humans
Pandemics
Pneumonia
SARS-CoV-2
Viral

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10.3390/ijms21218141

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abstract = "The 2019 novel coronavirus [2019-nCoV], which started to spread from December 2019 onwards, caused a global pandemic. Besides being responsible for the severe acute respiratory syndrome 2 [SARS-CoV-2], the virus can affect other organs causing various symptoms. A close relationship between SARS-CoV-2 and the cardiovascular system has been shown, demonstrating an epidemiological linkage between SARS-CoV-2 and cardiac injury. There are emerging data regarding possible direct myocardial damage by 2019-nCoV. In this review, the most important available evidences will be discussed to clarify the precise mechanisms of cardiovascular injury in SARS-CoV-2 patients, even if further researches are needed.",

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AU - Biscetti, Federico

AU - Rando, M. M.

AU - Nardella, E.

AU - Cecchini, A. L.

AU - Bruno, P.

AU - Landolfi, R.

AU - Flex, Andrea

PY - 2020

Y1 - 2020

N2 - The 2019 novel coronavirus [2019-nCoV], which started to spread from December 2019 onwards, caused a global pandemic. Besides being responsible for the severe acute respiratory syndrome 2 [SARS-CoV-2], the virus can affect other organs causing various symptoms. A close relationship between SARS-CoV-2 and the cardiovascular system has been shown, demonstrating an epidemiological linkage between SARS-CoV-2 and cardiac injury. There are emerging data regarding possible direct myocardial damage by 2019-nCoV. In this review, the most important available evidences will be discussed to clarify the precise mechanisms of cardiovascular injury in SARS-CoV-2 patients, even if further researches are needed.

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Cardiovascular disease and SARS-CoV-2: The role of host immune response versus direct viral injury

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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